islet amyloid polypeptide
Sign in to saveAlso known as insulinoma amyloid peptide, IAPP, amylin, Islet amyloid polypeptide (diabetes-associated peptide; amylin), DAP, diabetes-associated peptide
thumb|250px|right|Amino acid sequence of amylin with disulfide bridge and cleavage sites of insulin degrading enzyme indicated with arrows Amylin, or islet amyloid polypeptide (IAPP), is a 37-residue peptide hormone. It is co-secreted with insulin from the pancreatic β-cells in the ratio of approximately 100:1 (insulin:amylin). Amylin plays a role in glycemic regulation by slowing gastric emptying and promoting satiety, thereby preventing post-prandial spikes in blood glucose levels.
In the Vinony graph
Within Vinony's link graph, islet amyloid polypeptide is referenced by 323 other articles, and connects out to heart, endocrine system and PubMed.
It is catalogued under topics including Amylin receptor agonists, Amyloidosis and Diabetes.
Its subject is documented across 22 Wikipedia language editions.
Protein · UniProt
Islet amyloid polypeptide
- Gene
- IAPP
- Organism
- Homo sapiens (Human)
- Length
- 89 aa
- Molecular mass
- 9,806 Da
- Evidence
- 1: Evidence at protein level
Amylin/IAPP is a glucoregulatory peptide hormone that plays an important role in the regulation of energy homeostasis (PubMed:2690069). Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. IAPP function is mediated by the CALCR-RAMPs (AMYRs) receptor complexes (By similarity). Amylin can also bind CALCR receptor in the absence of RAMPs, although it is more selective for AMYRs (By similarity)
Swiss-Prot (reviewed) · via UniProt
Research
3,668 papers- Islet amyloid polypeptide: Another key molecule in Alzheimer's pathogenesis?Progress in neurobiology · 2017
- Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology.Journal of diabetes research · 2016
- Islet amyloid polypeptide and diabetes.Current protein & peptide science · 2013
- Islet amyloid polypeptide and type 2 diabetes.Experimental gerontology · 2003
- Human islet amyloid polypeptide (hIAPP) - a curse in type II diabetes mellitus: insights from structure and toxicity studies.Biological chemistry · 2021
via PubMed
Clinical Trials
97 registered- PHASE4COMPLETEDA Comparison of Adding Exenatide With Switching to Exenatide in Patients With Type 2 Diabetes Experiencing Inadequate Glycemic Control With Sitagliptin Plus MetforminAstraZeneca · NCT00870194
- PHASE3COMPLETEDExenatide Versus Glimepiride in Patients With Type 2 DiabetesAstraZeneca · NCT00359762
- PHASE1RECRUITINGUnderstanding the Effect of CagriSema, Cagrilintide, and Semaglutide on Muscle Health (Role of Amylin Signature in Muscle Health)Novo Nordisk A/S · NCT07527195
- PHASE2COMPLETEDA Pilot Study of Effects of Exenatide on Body Weight in Non-Diabetic, Obese PatientsAstraZeneca · NCT00500370
- PHASE1RECRUITINGA Study Looking at How Weekly Injections of Two Hormones - GIP and Amylin - Affect Stomach-related Side Effects in People Who Are Overweight or ObeseNovo Nordisk A/S · NCT07411560
- COMPLETEDExenatide and Basal Insulins Use in the Real Setting: an Observational Study in Patients With Type 2 DiabetesAstraZeneca · NCT01060059
Wikidata facts
- Instance of
- protein
Show 4 more facts
- found in taxon
- Homo sapiens
- cell component
- extracellular space
- exact match
- purl.uniprot.org/uniprot/P10997
- Commons category
- Amylin
via Wikidata · CC0
~12 min read
Encyclopedic overview
12 sectionsContents
- Synthesis
- Regulation
- Function
- Structure
- History
- Clinical significance
- Pharmacology
- Receptors
- See also
- References
- Further reading
- External links
thumb|250px|right|Amino acid sequence of amylin with disulfide bridge and cleavage sites of insulin degrading enzyme indicated with arrows Amylin, or islet amyloid polypeptide (IAPP), is a 37-residue peptide hormone. It is co-secreted with insulin from the pancreatic β-cells in the ratio of approximately 100:1 (insulin:amylin). Amylin plays a role in glycemic regulation by slowing gastric emptying and promoting satiety, thereby preventing post-prandial spikes in blood glucose levels.
IAPP is processed from an 89-residue coding sequence. Proislet amyloid polypeptide (proIAPP, proamylin, proislet protein) is produced in the pancreatic beta cells (β-cells) as a 67 amino acid, 7404 Dalton pro-peptide and undergoes post-translational modifications including protease cleavage to produce amylin.
Excerpted from Wikipedia’s “islet amyloid polypeptide” article, available under the CC BY-SA 4.0 licence.