islet amyloid polypeptide
Also known as insulinoma amyloid peptide, IAPP, amylin, Islet amyloid polypeptide (diabetes-associated peptide; amylin), DAP, diabetes-associated peptide
thumb|250px|right|Amino acid sequence of amylin with disulfide bridge and cleavage sites of insulin degrading enzyme indicated with arrows Amylin, or islet amyloid polypeptide (IAPP), is a 37-residue peptide hormone. It is co-secreted with insulin from the pancreatic β-cells in the ratio of approximately 100:1 (insulin:amylin). Amylin plays a role in glycemic regulation by slowing gastric emptying and promoting satiety, thereby preventing post-prandial spikes in blood glucose levels.
Research
3,668 papers- Islet amyloid polypeptide: Another key molecule in Alzheimer's pathogenesis?Progress in neurobiology · 2017
- Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology.Journal of diabetes research · 2016
- Islet amyloid polypeptide and diabetes.Current protein & peptide science · 2013
- Islet amyloid polypeptide and type 2 diabetes.Experimental gerontology · 2003
- Human islet amyloid polypeptide (hIAPP) - a curse in type II diabetes mellitus: insights from structure and toxicity studies.Biological chemistry · 2021
via PubMed
Clinical Trials
97 registered- PHASE4COMPLETED
~12 min read
Article
12 sectionsContents
- Synthesis
- Regulation
- Function
- Structure
- History
- Clinical significance
- Pharmacology
- Receptors
- See also
- References
- Further reading
- External links
thumb|250px|right|Amino acid sequence of amylin with disulfide bridge and cleavage sites of insulin degrading enzyme indicated with arrows Amylin, or islet amyloid polypeptide (IAPP), is a 37-residue peptide hormone. It is co-secreted with insulin from the pancreatic β-cells in the ratio of approximately 100:1 (insulin:amylin). Amylin plays a role in glycemic regulation by slowing gastric emptying and promoting satiety, thereby preventing post-prandial spikes in blood glucose levels.
IAPP is processed from an 89-residue coding sequence. Proislet amyloid polypeptide (proIAPP, proamylin, proislet protein) is produced in the pancreatic beta cells (β-cells) as a 67 amino acid, 7404 Dalton pro-peptide and undergoes post-translational modifications including protease cleavage to produce amylin.