Structure via PubChem · Public domain (PubChem)
buformin
Sign in to saveAlso known as DBV, 1-Butylbiguanide, W 37, Buformina, Buformine, Buforminum
Buformin (1-butylbiguanide) is an oral antidiabetic drug of the biguanide class, chemically related to metformin and phenformin. Buformin was marketed by German pharmaceutical company Grünenthal as Silubin.
Chemical data
- Formula
- C6H15N5
- Molecular weight
- 157.22 g/mol
- IUPAC name
- 2-butyl-1-(diaminomethylidene)guanidine
via PubChem
Drug data · ChEMBL
Withdrawn- Max clinical phase
- Approved
- Molecule type
- Small molecule
- Indications
- diabetes mellitus
via ChEMBL · EBI
Research
254 papers- A dual-functional buformin-mimicking poly(amido amine) for efficient and safe gene delivery.Journal of drug targeting · 2020
- Buformin suppresses osteosarcoma via targeting AMPK signaling pathway.Open life sciences · 2020
- Metformin: historical overview.Diabetologia · 2017
- Buformin suppresses proliferation and invasion via AMPK/S6 pathway in cervical cancer and synergizes with paclitaxel.Cancer biology & therapy · 2018
- Buformin exhibits anti-proliferative and anti-invasive effects in endometrial cancer cells.American journal of translational research · 2016
via PubMed
Wikidata facts
- Mass
- 157.133
Show 5 more facts
- chemical formula
- C₆H₁₅N₅
- canonical SMILES
- CCCCN=C(N)N=C(N)N
- isomeric SMILES
- CCCC/N=C(/N)\N=C(N)N
- defined daily dose
- 0.2
- Commons category
- Buformin
Sources (2)
via Wikidata · CC0
~5 min read
Article
11 sectionsContents
- Chemistry and animal toxicology
- Mechanism of action
- Pharmacokinetics
- Dosage
- Side effects and contraindications
- Toxicity
- Anticancer properties
- Antiviral properties
- History
- Synthesis
- References
Buformin (1-butylbiguanide) is an oral antidiabetic drug of the biguanide class, chemically related to metformin and phenformin. Buformin was marketed by German pharmaceutical company Grünenthal as Silubin.
==Chemistry and animal toxicology== Buformin hydrochloride is a fine, white to slightly yellow, crystalline, odorless powder, with a weakly acidic bitter taste. Its melting point is 174 to 177 °C, it is a strong base, and is freely soluble in water, methanol and ethanol, but insoluble in chloroform and ether. Toxicity: guinea pig LD50 subcutaneous 18 mg/kg; mouse LD50 intraperitoneal 140 mg/kg and 300 mg/kg oral. The log octanol-water partition coefficient (log P) is -1.20E+00; its water solubility is 7.46E+05 mg/L at 25 °C. Vapor pressure is 1.64E-04 mm Hg at 25 °C (EST); Henry's law constant is 8.14E-16 atm-m3/mole at 25 °C (EST). Its Atmospheric -OH rate constant is 1.60E-10 cm3/molecule-sec at 25 °C.