enterostatin
Sign in to saveAlso known as N2-[1-[N-(1-L-alanyl-L-prolyl)glycyl]-L-prolyl] L-Arginine, L-Alanyl-L-prolylglycyl-L-prolyl-L-Arginine, H-Ala-Pro-Gly-Pro-Arg-OH, APGPR
Enterostatin is a pentapeptide derived from a proenzyme in the gastrointestinal tract called procolipase. It reduces food intake, in particular fat intake, when given peripherally or into the brain.
Wikidata facts
- Mass
- 496.276
Show 3 more facts
- chemical formula
- C₂₁H₃₆N₈O₆
- canonical SMILES
- CC(C(=O)N1CCCC1C(=O)NCC(=O)N2CCCC2C(=O)NC(CCCN=C(N)N)C(=O)O)N
- isomeric SMILES
- C[C@@H](C(=O)N1CCC[C@H]1C(=O)NCC(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)N
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Article
6 sectionsContents
- Chemical structure
- Function
- Signaling pathway
- Effects
- Medical trials
- References
Enterostatin is a pentapeptide derived from a proenzyme in the gastrointestinal tract called procolipase. It reduces food intake, in particular fat intake, when given peripherally or into the brain.
== Chemical structure == Enterostatin has the sequence Val-Pro-Asp-Pro-Arg in most mammals, but Val-Pro-Gly-Pro-Arg or Val-Pro-Asp-Pro-Arg in rodents and Ala-Pro-Gly-Pro-Arg in humans. The sequence that it necessary for its anorexic effects is X-pro-Y-pro-arg and conserved among several vertebrate species.