enteropeptidase
Sign in to saveAlso known as enterokinase
Enteropeptidase (also called enterokinase) is an enzyme produced by cells of the duodenum and is involved in digestion in humans and other animals. Enteropeptidase converts trypsinogen (a zymogen) into its active form trypsin, resulting in the subsequent activation of digestive enzymes from the pancreas. Absence of enteropeptidase results in intestinal digestion impairment.
In the Vinony graph
Within Vinony's link graph, enteropeptidase is referenced by 153 other articles, and connects out to PubMed, PubMed Central and human chromosome 21.
Vinony files it under EC 3.4.21, Genes on human chromosome 21 and Protein pages needing a picture.
Its subject is documented across 20 Wikipedia language editions.
Key facts
- Enzyme.Name
- enteropeptidase
- Enzyme.EC_number
- 3.4.21.9
- Enzyme.CAS_number
- 9014-74-8
- Enzyme.GO_code
- 0004275
- Enzyme.image
- 1EKB.png
- Enzyme.caption
- Crystal structure of Enteropeptidase with an inhibitor
- Protein.Name
- protease, serine, 7 (enteropeptidase)
- Protein.HGNCid
- 9490
- Protein.Symbol
- TMPRSS15
- Protein.EntrezGene
- 5651
- Protein.OMIM
- 606635
- Protein.RefSeq
- NM_002772
- Protein.UniProt
- P98073
- Protein.Chromosome
- 21
- Protein.Arm
- q
- Protein.Band
- 21
via Wikipedia infobox
Research
569 papers- Enteropeptidase, a type II transmembrane serine protease.Frontiers in bioscience (Elite edition) · 2009
- Enterokinase (enteropeptidase): comparative aspects.Trends in biochemical sciences · 1989
- Enterokinase.Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) · 1994
- Enteropeptidase inhibitor SCO-792 effectively prevents kidney function decline and fibrosis in a rat model of chronic kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021
- Discovery and characterization of a small-molecule enteropeptidase inhibitor, SCO-792.Pharmacology research & perspectives · 2019
via PubMed
Wikidata facts
Show 2 more facts
- EC enzyme number
- 3.4.21.9
- Commons category
- Enteropeptidase (enterokinase light chain)
Sources (2)
via Wikidata · CC0
~7 min read
Encyclopedic overview
7 sectionsContents
- Historical significance
- Enzyme structure
- Activity
- Genetics and disease relevance
- Applications
- References
- External links
Enteropeptidase (also called enterokinase) is an enzyme produced by cells of the duodenum and is involved in digestion in humans and other animals. Enteropeptidase converts trypsinogen (a zymogen) into its active form trypsin, resulting in the subsequent activation of digestive enzymes from the pancreas. Absence of enteropeptidase results in intestinal digestion impairment.
Enteropeptidase is a serine protease () consisting of a disulfide-linked heavy-chain of 82-140 kDa that anchors enterokinase in the intestinal brush border membrane and a light-chain of 35–62 kDa that contains the catalytic subunit. Enteropeptidase is a part of the chymotrypsin-clan of serine proteases, and is structurally similar to these proteins.
Excerpted from Wikipedia’s “enteropeptidase” article, available under the CC BY-SA 4.0 licence.