APLP1

Also known as APLP, amyloid beta precursor like protein 1

Amyloid precursor like protein 1, also known as APLP1, is a protein encoded by the APLP1 gene in humans. APLP1 along with APLP2 are important modulators of glucose and insulin homeostasis.

In the Vinony graph

Within Vinony's link graph, APLP1 is referenced by 2 other articles, and connects out to PubMed, human chromosome 19 and Ensembl genome database project.

It sits within the topics Genes on human chromosome 19 and Parkinson's disease.

Its subject is documented across 5 Wikipedia language editions.

Gene data

APLP1

Name: amyloid beta precursor like protein 1
Type: protein-coding
Position: 35,867,899–35,879,803 (+)
Aliases: APLP
Ensembl: ENSG00000105290
RefSeq RNA: NM_001024807.3, NM_005166.5, XM_017026737.3, XM_017026738.3, XM_054320812.1
RefSeq protein: NP_001019978.1, NP_005157.1, XP_016882226.1, XP_016882227.1, XP_054176787.1

This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

amyloid beta precursor like protein 1

Symbol: APLP1
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:35,867,899-35,879,803
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: 3qmk.png

Show 8 more facts

HomoloGene ID: 68447
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/333
genomic end: 35879792
genomic start: 36358801
chromosome: human chromosome 19
cytogenetic location: 19q13.12
expressed in: hypothalamus

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

4 sections

Contents

Function
References
Further reading
External links

Amyloid precursor like protein 1, also known as APLP1, is a protein encoded by the APLP1 gene in humans. APLP1 along with APLP2 are important modulators of glucose and insulin homeostasis.

== Function ==

Excerpted from Wikipedia’s “APLP1” article, available under the CC BY-SA 4.0 licence.