RASGRP2
Sign in to saveAlso known as CALDAG-GEFI, CDC25L, RAS guanyl releasing protein 2
RAS guanyl-releasing protein 2 is a protein that in humans is encoded by the RASGRP2 gene.
Gene data
RASGRP2- Name
- RAS guanyl releasing protein 2
- Type
- protein-coding
- Aliases
- CALDAG-GEFI, CDC25L
The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Four alternatively spliced transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2016].
via MyGene.info
Gene · Ensembl
RAS guanyl releasing protein 2
- Symbol
- RASGRP2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:64,726,905-64,745,456
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 4250
- exact match
- identifiers.org/ncbigene/10235
- genomic end
- 64512928
- genomic start
- 64494383
- cytogenetic location
- 11q13.1
Sources (6)
via Wikidata · CC0
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Article
4 sectionsContents
- Clinical significance
- References
- Further reading
- External links
RAS guanyl-releasing protein 2 is a protein that in humans is encoded by the RASGRP2 gene.
The protein encoded by this gene is a brain-enriched nucleotide exchange factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Two alternatively spliced transcript variants of this gene, encoding distinct isoforms, have been reported.