RASGRP2
Sign in to saveAlso known as CALDAG-GEFI, CDC25L, RAS guanyl releasing protein 2
RAS guanyl-releasing protein 2 is a protein that in humans is encoded by the RASGRP2 gene.
Gene data
RASGRP2- Name
- RAS guanyl releasing protein 2
- Type
- protein-coding
- Position
- 64,726,905–64,745,456 (−)
- Aliases
- CALDAG-GEFI, CDC25L
- Ensembl
- ENSG00000068831
- RefSeq RNA
- NM_001098670.2, NM_001098671.2, NM_001318398.2, NM_001440690.1, NM_001440691.1
- RefSeq protein
- NP_001092140.1, NP_001092141.1, NP_001305327.1, NP_001427619.1, NP_001427620.1
The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Four alternatively spliced transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2016].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
RAS guanyl releasing protein 2
- Symbol
- RASGRP2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:64,726,905-64,745,456
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 4250
- exact match
- identifiers.org/ncbigene/10235
- found in taxon
- Homo sapiens
- genomic end
- 64512928
- genomic start
- 64494383
- chromosome
- human chromosome 11
- cytogenetic location
- 11q13.1
- expressed in
- left coronary artery
Sources (6)
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Clinical significance
- References
- Further reading
- External links
RAS guanyl-releasing protein 2 is a protein that in humans is encoded by the RASGRP2 gene.
The protein encoded by this gene is a brain-enriched nucleotide exchange factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Two alternatively spliced transcript variants of this gene, encoding distinct isoforms, have been reported.
Excerpted from Wikipedia’s “RASGRP2” article, available under the CC BY-SA 4.0 licence.