resistin
Sign in to saveAlso known as cysteine-rich secreted protein FIZZ3, found in inflammatory zone 3, resistin delta2, c/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein, RETN, cysteine-rich secreted protein A12-alpha-like 2, ADSF, C/EBP-epsilon regulated myeloid-specific secreted cysteine-rich protein precursor 1
Resistin, also known as adipose tissue-specific secretory factor (ADSF) or C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein (XCP1), is a cysteine-rich peptide hormone that is derived from adipose tissue and, in humans, is encoded by the RETN gene.
Key facts
- Protein family.Symbol
- Resistin
- Protein family.Name
- Resistin
- Protein family.Pfam
- PF06954
- Protein family.InterPro
- IPR009714
- Protein family.SCOP
- 1rgx
- Protein family.OPM family
- 384
- Protein family.OPM protein
- 1rgx
via Wikipedia infobox
Protein · UniProt
Resistin
- Gene
- RETN
- Organism
- Homo sapiens (Human)
- Length
- 108 aa
- Molecular mass
- 11,419 Da
- Evidence
- 1: Evidence at protein level
Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells (By similarity). Potentially links obesity to diabetes (By similarity). Promotes chemotaxis in myeloid cells (PubMed:15064728)
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
30 registered- COMPLETEDAdipocytokines, Gestational Diabetes Mellitus and Lipid MetabolismMedical University of Vienna · NCT02378675
- PHASE1/PHASE2COMPLETEDAzithromycin Versus Doxycycline on Restistin Level in Periodontitis Patients With Type 2 DiabetesKing Abdulaziz University · NCT06199440
- PHASE3WITHDRAWNTherapeutic Benefit of Preoperative Supplemental Vitamin D in Patients Undergoing Major Surgical Procedures.University of Missouri, Kansas City · NCT02138591
- NOT_YET_RECRUITINGCorrelation Between Serum Adiponectin And Resistin Levels And Degree of Hepatic Fibrosis in MASlD With type2 Diabetes MellitusSohag University · NCT06715189
- COMPLETEDRelationship Between Serum Resistin Levels and Reduction in Visceral Fat in Patients Undergoing Sleeve Gastrectomy Due to Morbid ObesitySercan YUKSEL, MD · NCT07564986
- NAUNKNOWNImpact of B. Bifidum 900791 Intake on Breast Milk Characteristics of Obese MothersUniversity of Chile · NCT03913364
Wikidata facts
Show 2 more facts
- Commons category
- Resistin
- exact match
- purl.uniprot.org/uniprot/Q9HD89
via Wikidata · CC0
~10 min read
Article
10 sectionsContents
- Discovery
- Structure
- Function
- Clinical significance
- Obesity and insulin resistance
- Arguments for
- Arguments against
- Inflammation
- References
- External links
Resistin, also known as adipose tissue-specific secretory factor (ADSF) or C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein (XCP1), is a cysteine-rich peptide hormone that is derived from adipose tissue and, in humans, is encoded by the RETN gene.
In primates, pigs, and dogs, resistin is secreted primarily by immune and epithelial cells, whereas in rodents, it is mainly secreted by adipose tissue. The human resistin pre-peptide consists of 108 amino acid residues, while in mice and rats it is 114 amino acids in length; the molecular weight is approximately 12.5 kDa. Resistin is classified as an adipose-derived hormone (similar to a cytokine), and its physiological role has been widely debated, particularly regarding its involvement in obesity and type II diabetes mellitus (T2DM).