RNF19A

Also known as RNF19, ring finger protein 19A, RBR E3 ubiquitin protein ligase

E3 ubiquitin-protein ligase RNF19A is an enzyme that in humans is encoded by the RNF19A gene.

Gene data

RNF19A

Name: ring finger protein 19A, RBR E3 ubiquitin protein ligase
Type: protein-coding
Aliases: RNF19

This gene encodes a member of the ring between ring fingers (RBR) protein family, and the encoded protein contains two RING-finger motifs and an in between RING fingers motif. This protein is an E3 ubiquitin ligase that is localized to Lewy bodies, and ubiquitylates synphilin-1, which is an interacting protein of alpha synuclein in neurons. The encoded protein may be involved in amyotrophic lateral sclerosis and Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].

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Gene · Ensembl

ring finger protein 19A, RBR E3 ubiquitin protein ligase

Symbol: RNF19A
Biotype: Protein coding
Organism: Homo sapiens
Location: 8:100,234,202-100,336,218
Strand: Reverse (−)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

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HomoloGene ID: 8501
exact match: identifiers.org/ncbigene/25897
genomic end: 101348446
genomic start: 101269288
cytogenetic location: 8q22.2

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E3 ubiquitin-protein ligase RNF19A is an enzyme that in humans is encoded by the RNF19A gene.

The protein encoded by this gene contains two RING-finger motifs and an IBR (in between RING fingers) motif. This protein is an E3 ubiquitin ligase that is localized in Lewy bodies (LBs), neuronal inclusions characteristic of Parkinson's disease (PD). This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. This protein is found to bind and ubiquitylate synphilin 1 (SNCAIP), which is an interacting protein of alpha-synuclein in neurons, and a major component of LB. Alternatively-spliced transcript variants encoding the same protein have been reported.