Structure via PubChem · Public domain (PubChem)
(RS)-propafenone
Sign in to saveAlso known as GNF-Pf-4594, 2-(2'-hydroxy-3'-propylaminopropoxy)-omega-phenylpropiophenone, 1-{2-[2-hydroxy-3-(propylamino)propoxy]phenyl}-3-phenyl-1-propanone
Propafenone, sold under the brand name Rythmol among others, is a class 1c anti-arrhythmic medication, which is used to treat illnesses associated with rapid heart beat such as atrial and ventricular arrhythmias.
In the Vinony graph
Vinony's link graph records 901 inbound references to (RS)-propafenone, and connects out to beta blocker, influenza vaccine and meningococcal vaccine.
It is catalogued under topics including Antiarrhythmic agents, CYP2D6 inhibitors and Drugboxes which contain changes to watched fields.
Vinony links it to 26 Wikipedia language editions.
Chemical data
- Formula
- C21H27NO3
- Molecular weight
- 341.4 g/mol
- IUPAC name
- 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one
- SMILES
- CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O
- InChIKey
- JWHAUXFOSRPERK-UHFFFAOYSA-N
- XLogP
- 3.3
- Polar surface area
- 58.6 Ų
- H-bond donors
- 2
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1989
- Admin. routes
- oral
- Indications
- atrial fibrillation, heart failure, cardiac arrhythmia, myocardial infarction
via ChEMBL · EBI
Research
1 papersvia PubMed
Wikidata facts
- Subclass of
- medication
- Mass
- 341.199
Show 6 more facts
- chemical formula
- C₂₁H₂₇NO₃
- significant drug interaction
- lidocaine
- medical condition treated
- supraventricular tachycardia
- canonical SMILES
- CCCNCC(COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2)O
- World Health Organisation international non-proprietary name
- propafenone
- Commons category
- Propafenone
via Wikidata · CC0
~5 min read
Encyclopedic overview
11 sectionsContents
- Mechanism of action
- Metabolism
- Side effects
- Initiation of therapy
- Contraindications and cautions
- History
- Stereochemistry
- See also
- References
- Further reading
- External links
{{drugbox | Watchedfields = changed | verifiedrevid = 464215884 | IUPAC_name = 1-{2-[2-Hydroxy-3-(propylamino)propoxy]phenyl}-3-phenylpropan-1-one | image = Propafenone Structure.svg | image_class = skin-invert-image | width = 200 | image2 = Propafenona ball-and-stick.png | image_class2 = bg-transparent | width2 = 200
| pronounce = | tradename = Rythmol, Rytmonorm, others | Drugs.com = | MedlinePlus = a698002 | DailyMedID = Propafenone | pregnancy_AU = | pregnancy_AU_comment = | pregnancy_US = N | pregnancy_US_comment = | pregnancy_category= | routes_of_administration = By mouth
Excerpted from Wikipedia’s “(RS)-propafenone” article, available under the CC BY-SA 4.0 licence.