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RWJ-51204
Sign in to saveRWJ-51204 is an anxiolytic drug used in scientific research. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic.
In the Vinony graph
Within Vinony's link graph, RWJ-51204 is referenced by 544 other articles, and connects out to benzodiazepine drug, GABAA receptor and alphenal.
It is catalogued under topics including 2-Fluorophenyl compounds, Abandoned drugs and Anilides.
Its subject is documented across 5 Wikipedia language editions.
Chemical data
- Formula
- C21H19F2N3O3
- Molecular weight
- 399.4 g/mol
- IUPAC name
- 5-(ethoxymethyl)-7-fluoro-N-(2-fluorophenyl)-3-oxo-1,2-dihydropyrido[1,2-a]benzimidazole-4-carboxamide
- SMILES
- CCOCN1C2=C(C=CC(=C2)F)N3C1=C(C(=O)CC3)C(=O)NC4=CC=CC=C4F
- InChIKey
- VQOQDABVGWLROX-UHFFFAOYSA-N
- XLogP
- 3.2
- Polar surface area
- 61.9 Ų
- H-bond donors
- 1
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 399.139448
Show 2 more facts
- chemical formula
- C₂₁H₁₉F₂N₃O₃
- canonical SMILES
- CCOCN1C2=C(C=CC(=C2)F)N3C1=C(C(=O)CC3)C(=O)NC4=CC=CC=C4F
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
RWJ-51204 is an anxiolytic drug used in scientific research. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic.
RWJ-51204 is a nonselective partial agonist at GABAA receptors. It produces primarily anxiolytic effects at low doses, with sedative, ataxia and muscle relaxant effects only appearing at some 20x the effective anxiolytic dose. It was discovered by researchers at the pharmaceutical company Johnson & Johnson, but its development has been discontinued.
Excerpted from Wikipedia’s “RWJ-51204” article, available under the CC BY-SA 4.0 licence.