S100A1

Also known as S100, S100-alpha, S100A, S100 calcium-binding protein A1, S100 calcium binding protein A1

Protein S100-A1, also known as S100 calcium-binding protein A1 is a protein which in humans is encoded by the S100A1 gene. S100A1 is highly expressed in cardiac and skeletal muscle, and localizes to Z-discs and sarcoplasmic reticulum. S100A1 has shown promise as an effective candidate for gene therapy to treat post-myocardially infarcted cardiac tissue.

Gene data

S100A1

Name: S100 calcium binding protein A1
Type: protein-coding
Aliases: S100, S100-alpha, S100A

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008].

via MyGene.info

Wikidata facts

Image: Protein S100A1 PDB 1k2h.png

Sources (4)

~9 min read

Article

13 sections

Contents

Structure
Function
Clinical significance
Expression changes in disease
Cardiac disease
Therapeutic potential
Biomarker potential
Drug interactions
Research
Interactions
References
Further reading
External links

== Structure == S100A1 is a member of the S100 family of proteins expressed in cardiac muscle, skeletal muscle, and the brain, with the highest density at Z-lines and the sarcoplasmic reticulum. In its dimerized form, S100A1 contains four EF-hand calcium-binding motifs, and can exist as either a heterodimer or a homodimer. The homodimer is a high-affinity complex (nanomolar range or tighter) stabilized by hydrophobic packing within an X-type four-helix bundle formed by helices 1, 1, 4, and 4.