Structure via PubChem · Public domain (PubChem)
SB-203580
Sign in to saveAlso known as PB 203580, RWJ 64809, SB203580, 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole, SB 203580
chemical compound
Chemical data
- Formula
- C21H16FN3OS
- Molecular weight
- 377.4 g/mol
- IUPAC name
- 4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine
- SMILES
- CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F
- InChIKey
- CDMGBJANTYXAIV-UHFFFAOYSA-N
- XLogP
- 3.2
- Polar surface area
- 77.9 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
3,997 papers- Specificity and mechanism of action of some commonly used protein kinase inhibitors.The Biochemical journal · 2000
- SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1.FEBS letters · 1995
- SB 203580, an inhibitor of p38 MAPK, abolishes infarct-limiting effect of ischemic preconditioning in isolated rabbit hearts.Basic research in cardiology · 2000
- Effect of SB 203580 on the activity of c-Raf in vitro and in vivo.Oncogene · 1999
- SB 203580, a mitogen-activated protein kinase inhibitor, abolishes resistance to myocardial infarction induced by heat stress.Cardiovascular drugs and therapy · 2000
via PubMed
Wikidata facts
- Mass
- 377.099811
Show 3 more facts
- chemical formula
- C₂₁H₁₆FN₃OS
- canonical SMILES
- CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F
- found in taxon
- Annulohypoxylon truncatum
via Wikidata · CC0