SCIN
Sign in to saveAlso known as scinderin
Scinderin (also known as adseverin) is a protein that in humans is encoded by the SCIN gene. Scinderin is an actin severing protein belonging to the gelsolin superfamily. It was discovered in Dr. Trifaro's laboratory at the University of Ottawa, Canada. Secretory tissues are rich in scinderin. In these tissues scinderin, a calcium dependent protein, regulates cortical actin networks. Normally secretory vesicles are excluded from release sites on the plasma membrane by the presence of a cortical actin filament network. During cell stimulation, calcium channels open allowing calcium ions to ente
Gene data
SCIN- Name
- scinderin
- Type
- protein-coding
- Position
- 12,570,577–12,660,182 (+)
- Ensembl
- ENSG00000006747
- RefSeq RNA
- NM_001112706.3, NM_033128.3, NR_156701.2
- RefSeq protein
- NP_001106177.1, NP_149119.1
SCIN is a Ca(2+)-dependent actin-severing and -capping protein (Zunino et al., 2001 [PubMed 11568009]).[supplied by OMIM, May 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
scinderin
- Symbol
- SCIN
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:12,570,577-12,660,182
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 36296
- exact match
- identifiers.org/ncbigene/85477
- genomic end
- 12660182
- genomic start
- 12610203
- cytogenetic location
- 7p21.3
Sources (4)
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- References
- Further reading
Scinderin (also known as adseverin) is a protein that in humans is encoded by the SCIN gene. Scinderin is an actin severing protein belonging to the gelsolin superfamily. It was discovered in Dr. Trifaro's laboratory at the University of Ottawa, Canada. Secretory tissues are rich in scinderin. In these tissues scinderin, a calcium dependent protein, regulates cortical actin networks. Normally secretory vesicles are excluded from release sites on the plasma membrane by the presence of a cortical actin filament network. During cell stimulation, calcium channels open allowing calcium ions to enter the secretory cell. Increase in intracellular calcium activates scinderin with the consequent actin filament severing and local dissociation of actin filament networks. This allows the movement of secretory vesicles to release sites on the plasma membrane.
== References ==