SCYL1
Sign in to saveAlso known as GKLP, NKTL, NTKL, P105, TAPK, TEIF, TRAP, HT019
SCY1-like 1 (S. cerevisiae), also known as SCYL1, is a human gene which is highly conserved throughout evolution.
Gene data
SCYL1- Name
- SCY1 like pseudokinase 1
- Type
- protein-coding
- Position
- 65,525,044–65,538,711 (+)
- Aliases
- GKLP, HT019, NKTL, NTKL, P105, SCAR21, TAPK, TEIF, TRAP
- Ensembl
- ENSG00000142186
- RefSeq RNA
- NM_001048218.2, NM_001411022.1, NM_001425179.1, NM_001425180.1, NM_001425181.1
- RefSeq protein
- NP_001041683.1, NP_001397951.1, NP_001412108.1, NP_001412109.1, NP_001412110.1
This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
SCY1 like pseudokinase 1
- Symbol
- SCYL1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:65,525,044-65,538,711
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- Commons category
- SCYL1
- HomoloGene ID
- 6947
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/57410
- genomic end
- 65306175
- genomic start
- 65292548
- chromosome
- human chromosome 11
- cytogenetic location
- 11q13.1
Sources (4)
via Wikidata · CC0
~2 min read
Encyclopedic overview
4 sectionsContents
- Function
- Clinical significance
- References
- Further reading
SCY1-like 1 (S. cerevisiae), also known as SCYL1, is a human gene which is highly conserved throughout evolution.
== Function == This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. At least three of the transcripts code for a protein containing all exons, referred to as full-length (FL).
Excerpted from Wikipedia’s “SCYL1” article, available under the CC BY-SA 4.0 licence.