SFRP2
Sign in to saveAlso known as FRP-2, SARP1, SDF-5, secreted frizzled related protein 2
Secreted frizzled-related protein 2 is a protein that in humans is encoded by the SFRP2 gene. This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer.
Gene data
SFRP2- Name
- secreted frizzled related protein 2
- Type
- protein-coding
- Position
- 153,780,544–153,791,620 (−)
- Aliases
- FRP-2, SARP1, SDF-5
- Ensembl
- ENSG00000145423
- RefSeq RNA
- NM_003013.3
- RefSeq protein
- NP_003004.1
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
secreted frizzled related protein 2
- Symbol
- SFRP2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 4:153,780,544-153,791,620
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~1 min read
Encyclopedic overview
3 sectionsContents
- Cancer
- References
- Further reading
Secreted frizzled-related protein 2 is a protein that in humans is encoded by the SFRP2 gene. This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer.
New cardiomyocytes can be regenerated in the mouse heart via Sfrp2 and this may lead to treatment of heart injury .
Excerpted from Wikipedia’s “SFRP2” article, available under the CC BY-SA 4.0 licence.