simeprevir
Sign in to saveAlso known as Olysio®, simeprevir sodium, TMC 435, TMC 435350, TMC-435, TMC435
Simeprevir, sold under the brand name Olysio among others, is a medication used in combination with other medications for the treatment of hepatitis C. It is specifically used for hepatitis C genotype 1 and 4. Medications it is used with include sofosbuvir or ribavirin and peginterferon-alfa. Cure rates are in 80s to 90s percent. It may be used in those who also have HIV/AIDS. It is taken by mouth once daily for typically 12 weeks.
Research
944 papers- Simeprevir.2012
- Simeprevir.Australian prescriber · 2015
- Simeprevir: first global approval.Drugs · 2013
- Simeprevir induces ferroptosis through β-TrCP/Nrf2/GPX4 axis in triple-negative breast cancer cells.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2024
- Simeprevir and sofosbuvir for treatment of hepatitis C infection.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2015
via PubMed
Wikidata facts
- Mass
- 749.292
Show 5 more facts
- chemical formula
- C₃₈H₄₇N₅O₇S₂
- isomeric SMILES
- CC1=C(C=CC2=C1N=C(C=C2O[C@@H]3C[C@@H]4[C@@H](C3)C(=O)N(CCCC/C=C\[C@@H]5C[C@]5(NC4=O)C(=O)NS(=O)(=O)C6CC6)C)C7=NC(=CS7)C(C)C)OC
- canonical SMILES
- CC1=C(C=CC2=C1N=C(C=C2OC3CC4C(C3)C(=O)N(CCCCC=CC5CC5(NC4=O)C(=O)NS(=O)(=O)C6CC6)C)C7=NC(=CS7)C(C)C)OC
- Commons category
- Simeprevir
- defined daily dose
- 0.15
Sources (7)
via Wikidata · CC0
~10 min read
Article
16 sectionsContents
- Medical use
- Dosing
- Contraindications
- Pregnancy
- Adverse effects
- Combination treatment
- Mechanism of action
- Pharmacokinetics
- Pharmacogenomics
- Drug interactions
- Approval
- Clinical study
- SARS-CoV-2 research
- References
- Further reading
- External links
{{Drugbox | drug_name = | IUPAC_name = (2R,3aR,10Z,11aS,12aR,14aR)-N-(Cyclopropylsulfonyl)-2-{[2-(4-isopropyl-1,3-thiazol-2-yl)-7-methoxy-8-methyl-4-quinolinyl]oxy}-5-methyl-4,14-dioxo-2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydrocyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a(1H)-carboxamide | image = Simeprevir.svg | image_class = skin-invert-image | width = 200 | alt = | caption =
| pronounce = | tradename = Olysio, Sovriad, Galexos, others | Drugs.com = | MedlinePlus = a614013 | licence_EU = yes | DailyMedID = Simeprevir | pregnancy_AU = | pregnancy_category = | routes_of_administration = By mouth | ATCvet = | ATC_prefix = J05 | ATC_suffix = AP05