SNTG1

Also known as G1SYN, SYN4, syntrophin gamma 1

Gamma-1-syntrophin is a protein that in humans is encoded by the SNTG1 gene.

Gene data

SNTG1

Name: syntrophin gamma 1
Type: protein-coding
Position: 49,909,789–50,796,692 (+)
Aliases: G1SYN, SYN4
Ensembl: ENSG00000147481
RefSeq RNA: NM_001287813.3, NM_001287814.3, NM_001321773.2, NM_001321775.2, NM_001321776.2
RefSeq protein: NP_001274742.1, NP_001274743.1, NP_001308702.1, NP_001308704.1, NP_001308705.1

The protein encoded by this gene is a member of the syntrophin family. Syntrophins are cytoplasmic peripheral membrane proteins that typically contain 2 pleckstrin homology (PH) domains, a PDZ domain that bisects the first PH domain, and a C-terminal domain that mediates dystrophin binding. This family member plays a role in mediating gamma-enolase trafficking to the plasma membrane and in enhancing its neurotrophic activity. Mutations in this gene are associated with idiopathic scoliosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016].

Gene Ontology

Biological process

cell communication synaptic signaling

Molecular function

structural molecule activity protein binding

Cellular component

nucleus cytoplasm cytoskeleton cytoskeleton plasma membrane dystrophin-associated glycoprotein complex syntrophin complex syntrophin complex

via MyGene.info

Gene · Ensembl

syntrophin gamma 1

Symbol: SNTG1
Biotype: Protein coding
Organism: Homo sapiens
Location: 8:49,909,789-50,796,692
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 56834
exact match: identifiers.org/ncbigene/54212
genomic end: 50796692
genomic start: 50822349
cytogenetic location: 8q11.21

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Gamma-1-syntrophin is a protein that in humans is encoded by the SNTG1 gene.

The protein encoded by this gene is a member of the syntrophin family. Syntrophins are cytoplasmic peripheral membrane proteins that typically contain 2 pleckstrin homology (PH) domains, a PDZ domain that bisects the first PH domain, and a C-terminal domain that mediates dystrophin binding. This gene is specifically expressed in the brain. Transcript variants for this gene have been described, but their full-length nature has not been determined.