SNTG1
Sign in to saveAlso known as G1SYN, SYN4, syntrophin gamma 1
Gamma-1-syntrophin is a protein that in humans is encoded by the SNTG1 gene.
Gene data
SNTG1- Name
- syntrophin gamma 1
- Type
- protein-coding
- Position
- 49,909,789–50,796,692 (+)
- Aliases
- G1SYN, SYN4
- Ensembl
- ENSG00000147481
- RefSeq RNA
- NM_001287813.3, NM_001287814.3, NM_001321773.2, NM_001321775.2, NM_001321776.2
- RefSeq protein
- NP_001274742.1, NP_001274743.1, NP_001308702.1, NP_001308704.1, NP_001308705.1
The protein encoded by this gene is a member of the syntrophin family. Syntrophins are cytoplasmic peripheral membrane proteins that typically contain 2 pleckstrin homology (PH) domains, a PDZ domain that bisects the first PH domain, and a C-terminal domain that mediates dystrophin binding. This family member plays a role in mediating gamma-enolase trafficking to the plasma membrane and in enhancing its neurotrophic activity. Mutations in this gene are associated with idiopathic scoliosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
syntrophin gamma 1
- Symbol
- SNTG1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 8:49,909,789-50,796,692
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 56834
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/54212
- genomic end
- 50796692
- genomic start
- 50822349
- chromosome
- human chromosome 8
- cytogenetic location
- 8q11.21
- expressed in
- caudate nucleus
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Gamma-1-syntrophin is a protein that in humans is encoded by the SNTG1 gene.
The protein encoded by this gene is a member of the syntrophin family. Syntrophins are cytoplasmic peripheral membrane proteins that typically contain 2 pleckstrin homology (PH) domains, a PDZ domain that bisects the first PH domain, and a C-terminal domain that mediates dystrophin binding. This gene is specifically expressed in the brain. Transcript variants for this gene have been described, but their full-length nature has not been determined.
Excerpted from Wikipedia’s “SNTG1” article, available under the CC BY-SA 4.0 licence.