SOSTDC1

Name

sclerostin domain containing 1

Type

protein-coding

Position

16,461,481–16,530,580 (−)

Aliases

CDA019, DAND7, ECTODIN, USAG1

Ensembl

ENSG00000171243

RefSeq RNA

NM_015464.3

RefSeq protein

NP_056279.1

This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death. [provided by RefSeq, Jul 2008].