SRGN
Sign in to saveAlso known as PPG, PRG, PRG1, serglycin
Serglycin, also known as hematopoietic proteoglycan core protein or secretory granule proteoglycan core protein, is a protein that in humans is encoded by the SRGN gene. It is primarily expressed in hematopoietic cells and endothelial cells, and is the only known intracellular proteoglycan.
Gene data
SRGN- Name
- serglycin
- Type
- protein-coding
- Aliases
- PPG, PRG, PRG1
This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene. [provided by RefSeq, Jul 2010].
via MyGene.info
Gene · Ensembl
serglycin
- Symbol
- SRGN
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 10:69,087,579-69,105,696
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- exact match
- identifiers.org/ncbigene/5552
- HomoloGene ID
- 2043
- genomic end
- 69104805
- genomic start
- 69088103
- cytogenetic location
- 10q22.1
Sources (4)
via Wikidata · CC0
~1 min read
Article
3 sectionsContents
- Function
- References
- Further reading
Serglycin, also known as hematopoietic proteoglycan core protein or secretory granule proteoglycan core protein, is a protein that in humans is encoded by the SRGN gene. It is primarily expressed in hematopoietic cells and endothelial cells, and is the only known intracellular proteoglycan.
== Function ==