STK35
Sign in to saveAlso known as serine/threonine kinase 35, CLIK1, STK35L1, Serine/threonine kinase 35
STK35L1 is a protein that in humans is encoded by the STK35 (serine/threonine kinase 35) gene. It is a member of the NKF4 (New Kinase Family 4) Ser/Thr kinases (STK) family and classified in group "Other" in the human kinome. Previously, STK35L1 was named as Clik1 (CLP36 Interacting Kinase 1) based on a study that showed an association of STK35 with CLP36 after overexpression of both proteins in osteosarcoma cells. Clik1 gene described by Vallenius et al. code for a protein of 501 amino acids. Later, Goyal et al. found that coding sequence of the STK35 gene is incomplete. The newly identified
Gene data
STK35- Name
- serine/threonine kinase 35
- Type
- protein-coding
- Aliases
- CLIK1, STK35L1
The protein encoded by this gene is a kinase that is predominantly found in the nucleus. However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. The encoded protein may be a regulator of actin stress fibers in nonmuscle cells. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
serine/threonine kinase 35
- Symbol
- STK35
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:2,101,767-2,177,038
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 15441
- exact match
- identifiers.org/ncbigene/140901
- genomic end
- 2157684
- genomic start
- 2101827
- cytogenetic location
- 20p13
Sources (3)
via Wikidata · CC0
~1 min read
Article
3 sectionsContents
- Functions
- References
- Further reading
STK35L1 is a protein that in humans is encoded by the STK35 (serine/threonine kinase 35) gene. It is a member of the NKF4 (New Kinase Family 4) Ser/Thr kinases (STK) family and classified in group "Other" in the human kinome. Previously, STK35L1 was named as Clik1 (CLP36 Interacting Kinase 1) based on a study that showed an association of STK35 with CLP36 after overexpression of both proteins in osteosarcoma cells. Clik1 gene described by Vallenius et al. code for a protein of 501 amino acids. Later, Goyal et al. found that coding sequence of the STK35 gene is incomplete. The newly identified sequence of the STK35 gene codes for a protein of 534 amino acids with a N-terminal elongation of 133 amino acids. It has been designated as STK35L1.
==Functions== STK35L1 is predominantly found in the nucleus and the nucleolus. Nuclear actin was identified as a novel binding partner of STK35L1. However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. STK35L1 regulates the expression of CDKN2A and inhibiting G1- to S-phase transition. Depletion of STK35L1 by siRNA impaired endothelial cell migration. STK35L1 may act as a central kinase linking the cell cycle and migration of endothelial cells.