sydnones
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Sydnones are mesoionic heterocyclic chemical compounds possessing a C5-oxygenated 1,2,3-oxadiazole core, named after the city of Sydney, Australia. Like other mesoionic compounds they are dipolar, possessing both positive and negative charges which are delocalized across the ring.
Research
2,450 papers- Sydnones: a brief review.Mini reviews in medicinal chemistry · 2012
- A mechanochemical approach to the synthesis of sydnones and derivatives.Faraday discussions · 2023
- Synthesis of sydnonimines from sydnones and their use for bioorthogonal release of isocyanates in cells.Chemical communications (Cambridge, England) · 2024
- Antiinflammatory sydnones. 1.Journal of medicinal chemistry · 1974
- Investigation of mitochondrial targeting ability of sydnones and sydnonimines and mitochondria-targeted delivery of celecoxib.Bioorganic & medicinal chemistry letters · 2023
via PubMed
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Encyclopedic overview
7 sectionsContents
- Discovery
- Chemical structure
- Examples
- Related compounds
- See also
- References
- External links
Sydnones are mesoionic heterocyclic chemical compounds possessing a C5-oxygenated 1,2,3-oxadiazole core, named after the city of Sydney, Australia. Like other mesoionic compounds they are dipolar, possessing both positive and negative charges which are delocalized across the ring.
== Discovery == N-phenylsydnone was first prepared in 1935 by John Campbell Earl and by cyclodehydration of N-Nitroso-N-phenylglycine with acetic anhydride. Later work showed that this could be applied fairly generally to the nitrosamines of N-substituted amino acids.
Excerpted from Wikipedia’s “sydnones” article, available under the CC BY-SA 4.0 licence.