TFF3
Sign in to saveAlso known as ITF, P1B, TFI, trefoil factor 3
protein-coding gene in the species Homo sapiens
Gene data
TFF3- Name
- trefoil factor 3
- Type
- protein-coding
- Position
- 42,311,667–42,315,409 (−)
- Aliases
- ITF, P1B, TFI
- Ensembl
- ENSG00000160180
- RefSeq RNA
- NM_003226.4
- RefSeq protein
- NP_003217.4
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008].
Gene Ontology
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
trefoil factor 3
- Symbol
- TFF3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 21:42,311,667-42,315,530
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein TFF3 PDB 1e9t.png
Show 5 more facts
- HomoloGene ID
- 2427
- exact match
- identifiers.org/ncbigene/7033
- genomic end
- 42315409
- genomic start
- 43731777
- cytogenetic location
- 21q22.3
Sources (4)
via Wikidata · CC0