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GeneQ18035410· pop 5· linked from 9 articles

TIMM44

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Also known as TIM44, translocase of inner mitochondrial membrane 44

Mitochondrial import inner membrane translocase subunit TIM44 is an enzyme that in humans is encoded by the TIMM44 gene.

Gene data

TIMM44

Name: translocase of inner mitochondrial membrane 44
Type: protein-coding
Position: 7,926,715–7,943,773 (−)
Aliases: TIM44
Ensembl: ENSG00000104980
RefSeq RNA: NM_006351.4
RefSeq protein: NP_006342.2

This gene encodes a peripheral membrane protein associated with the mitochondrial inner membrane translocase, which functions in the import of proteins across the mitochondrial inner membrane and into the mitochondrial matrix. The encoded protein mediates binding of mitochondrial heat shock protein 70 to the translocase of inner mitochondrial membrane 23 (TIM23) complex. Expression of this gene is upregulated in kidney in a mouse model of diabetes. A mutation in this gene is associated with familial oncocytic thyroid carcinoma. [provided by RefSeq, Jul 2016].

Gene Ontology

Biological process

intracellular protein transport protein import into mitochondrial matrix protein import into mitochondrial matrix protein import into mitochondrial matrix

Molecular function

protein binding protein-folding chaperone binding protein-folding chaperone binding

Cellular component

PAM complex, Tim23 associated import motor mitochondrion mitochondrion mitochondrial inner membrane mitochondrial inner membrane mitochondrial inner membrane TIM23 mitochondrial import inner membrane translocase complex TIM23 mitochondrial import inner membrane translocase complex

Pathways

Mitochondrial protein import Protein localization

via MyGene.info

Gene · Ensembl

translocase of inner mitochondrial membrane 44

Symbol: TIMM44
Biotype: Protein coding
Organism: Homo sapiens
Location: 19:7,926,715-7,943,773
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein TIMM44 PDB 2cw9.png

Show 8 more facts

HomoloGene ID: 4631
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/10469
genomic end: 7943667
genomic start: 7991603
chromosome: human chromosome 19
cytogenetic location: 19p13.2
expressed in: gastric mucosa

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

5 sections

Contents

Interactions
See also
References
Further reading
External links

Mitochondrial import inner membrane translocase subunit TIM44 is an enzyme that in humans is encoded by the TIMM44 gene.

==Interactions== TIMM44 has been shown to interact with ARAF.

Excerpted from Wikipedia’s “TIMM44” article, available under the CC BY-SA 4.0 licence.

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