Structure via PubChem · Public domain (PubChem)
tizoxanide
Sign in to saveTizoxanide, also known as desacetyl-nitazoxanide, is a thiazolide and an antiparasitic agent that occurs as a metabolite of nitazoxanide in humans through hydrolysis. Tizoxanide may undergo further metabolism via conjugation into tizoxanide glucuronide.
In the Vinony graph
Vinony's link graph records 3 inbound references to tizoxanide, and connects out to digital object identifier, chemical formula and organic compound.
Vinony files it under ECHA InfoCard ID from Wikidata, Human drug metabolites and Nitrothiazoles.
Vinony links it to 6 Wikipedia language editions.
Chemical data
- Formula
- C10H7N3O4S
- Molecular weight
- 265.25 g/mol
- IUPAC name
- 2-hydroxy-N-(5-nitro-1,3-thiazol-2-yl)benzamide
- SMILES
- C1=CC=C(C(=C1)C(=O)NC2=NC=C(S2)[N+](=O)[O-])O
- InChIKey
- FDTZUTSGGSRHQF-UHFFFAOYSA-N
- XLogP
- 3.2
- Polar surface area
- 136 Ų
- H-bond donors
- 2
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
104 papers- Tizoxanide Antiviral Activity on Dengue Virus Replication.Viruses · 2023
- Tizoxanide as a novel theraputic candidate for osteoarthritis.Heliyon · 2023
- Nitazoxanide.2006
- Tizoxanide Promotes Apoptosis in Glioblastoma by Inhibiting CDK1 Activity.Frontiers in pharmacology · 2022
- Tizoxanide induces autophagy by inhibiting PI3K/Akt/mTOR pathway in RAW264.7 macrophage cells.Archives of pharmacal research · 2020
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 265.016
Show 3 more facts
- chemical formula
- C₁₀H₇N₃O₄S
- canonical SMILES
- C1=CC=C(C(=C1)C(=O)NC2=NC=C(S2)[N+](=O)[O-])O
- Commons category
- Tizoxanide
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Tizoxanide, also known as desacetyl-nitazoxanide, is a thiazolide and an antiparasitic agent that occurs as a metabolite of nitazoxanide in humans through hydrolysis. Tizoxanide may undergo further metabolism via conjugation into tizoxanide glucuronide.
==References==
Excerpted from Wikipedia’s “tizoxanide” article, available under the CC BY-SA 4.0 licence.