Structure via PubChem · Public domain (PubChem)
droperidol
Sign in to saveAlso known as McN-JR-4749, R-4749, 1-{1-[4-(4-fluoro-phenyl)-4-oxo-butyl]-1,2,3,6-tetrahydro-pyridin-4-yl}-1,3-dihydro-benzoimidazol-2-one, 1-{1-[3-(p-fluorobenzoyl)propyl]-1,2,3,6-tetrahydro-4-pyridyl}-2-benzimidazolinone, 1-{1-[4-(p-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridyl}-2-benzimidazolinone, 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridinyl}-2,3-dihydro-1H-benzo[d]imidazol-2-one
Droperidol (Inapsine, Droleptan, Dridol, Xomolix, Innovar [combination with fentanyl]) is an antidopaminergic drug used as an antiemetic (that is, to prevent or treat nausea) and as an antipsychotic. Droperidol is also often used as a rapid sedative in intensive-care treatment, and where "agitation aggression or violent behavior" are present.
Chemical data
- Formula
- C22H22FN3O2
- Molecular weight
- 379.4 g/mol
- IUPAC name
- 3-[1-[4-(4-fluorophenyl)-4-oxobutyl]-3,6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one
- SMILES
- C1CN(CC=C1N2C3=CC=CC=C3NC2=O)CCCC(=O)C4=CC=C(C=C4)F
- InChIKey
- RMEDXOLNCUSCGS-UHFFFAOYSA-N
- XLogP
- 3.5
- Polar surface area
- 52.7 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Research
2,938 papers- Droperidol Use in the Emergency Department: A Clinical Review.The Journal of emergency medicine · 2023
- Reintegrating droperidol into emergency medicine practice.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2020
- Midazolam-Droperidol, Droperidol, or Olanzapine for Acute Agitation: A Randomized Clinical Trial.Annals of emergency medicine · 2017
- Droperidol in the emergency department: is it safe?The Journal of emergency medicine · 2003
- Droperidol for the treatment of acute migraine headaches.The Annals of pharmacotherapy · 2015
via PubMed
Wikidata facts
- Mass
- 379.169605
Show 6 more facts
- MCN code
- 2933.39.12
- chemical formula
- C₂₂H₂₂FN₃O₂
- World Health Organisation international non-proprietary name
- droperidolum
- canonical SMILES
- C1CN(CC=C1N2C3=CC=CC=C3NC2=O)CCCC(=O)C4=CC=C(C=C4)F
- Commons category
- Droperidol
- defined daily dose
- 2.5
Sources (8)
via Wikidata · CC0
~3 min read
Article
6 sectionsContents
- History
- Medical use
- Black box warning
- Side effects
- References
- Further reading
Droperidol (Inapsine, Droleptan, Dridol, Xomolix, Innovar [combination with fentanyl]) is an antidopaminergic drug used as an antiemetic (that is, to prevent or treat nausea) and as an antipsychotic. Droperidol is also often used as a rapid sedative in intensive-care treatment, and where "agitation aggression or violent behavior" are present.
== History == Discovered at Janssen Pharmaceutica in 1961, droperidol is a butyrophenone which acts as a potent D2 (dopamine receptor) antagonist with some histamine and serotonin antagonist activity.