toxicokinetics

Toxicokinetics (often abbreviated as 'TK') is the description of both what rate a chemical will enter the body and what occurs to excrete and metabolize the compound once it is in the body.

==Relation to pharmacokinetics== It is an application of pharmacokinetics to determine the relationship between the systemic exposure of a compound and its toxicity. It is used primarily for establishing relationships between exposures in toxicology experiments in animals and the corresponding exposures in humans. However, it can also be used in environmental risk assessments in order to determine the potential effects of releasing chemicals into the environment. In order to quantify toxic effects, toxicokinetics can be combined with toxicodynamics. Such toxicokinetic-toxicodynamic (TKTD) models are used in ecotoxicology.