TP53BP2
Sign in to saveAlso known as 53BP2, ASPP2, BBP, P53BP2, PPP1R13A, tumor protein p53 binding protein 2
Apoptosis-stimulating of p53 protein 2 (ASPP2) also known as Bcl2-binding protein (Bbp) and tumor suppressor p53-binding protein 2 (p53BP2) is a protein that in humans is encoded by the TP53BP2 gene. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene data
TP53BP2- Name
- tumor protein p53 binding protein 2
- Type
- protein-coding
- Aliases
- 53BP2, ASPP2, BBP, P53BP2, PPP1R13A
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
tumor protein p53 binding protein 2
- Symbol
- TP53BP2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:223,779,893-223,846,012
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein TP53BP2 PDB 1ycs.png
Show 5 more facts
- HomoloGene ID
- 3959
- exact match
- identifiers.org/ncbigene/7159
- genomic end
- 223845954
- genomic start
- 223779893
- cytogenetic location
- 1q41
Sources (3)
via Wikidata · CC0
~5 min read
Article
9 sectionsContents
- Nomenclature
- Function
- Structure
- Family members
- Binding partners
- Expression
- Clinical significance
- References
- Further reading
Apoptosis-stimulating of p53 protein 2 (ASPP2) also known as Bcl2-binding protein (Bbp) and tumor suppressor p53-binding protein 2 (p53BP2) is a protein that in humans is encoded by the TP53BP2 gene. Multiple transcript variants encoding different isoforms have been found for this gene.
== Nomenclature ==