Structure via PubChem · Public domain (PubChem)
tremorine
Sign in to saveAlso known as 1-(4-pyrrolidin-1-ylbut-2-ynyl)pyrrolidine
Tremorine is a drug which is used in scientific research to produce tremor in animals. This is used for the development of drugs for the treatment of Parkinson's disease, as tremor is a major symptom which is treated by anti-Parkinson's drugs. Beta blockers are also effective in counteracting the effects of tremorine.
Chemical data
- Formula
- C12H20N2
- Molecular weight
- 192.3 g/mol
- IUPAC name
- 1-(4-pyrrolidin-1-ylbut-2-ynyl)pyrrolidine
- SMILES
- C1CCN(C1)CC#CCN2CCCC2
- InChIKey
- JSUAJTLKVREZHV-UHFFFAOYSA-N
- XLogP
- 1.3
- Polar surface area
- 6.5 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
412 papers- TREMORINE-INDUCED TREMOR VERSUS EXTRAPYRAMIDAL DISEASE.Nature · 1964
- Tolerance to tremorine.Acta physiologica Academiae Scientiarum Hungaricae · 1961
- Use of tremorine for screening anti-parkinsonian drugs.Nature · 1959
- TREMORINE: ITS PERIPHERAL ACTION ON STRIATED MUSCLE.Science (New York, N.Y.) · 1964
- Possible involvement of 5-hydroxytryptamine and cyclic-AMP in tolerance to tremorine analgesia in mice.Psychopharmacology · 1977
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 192.163
Show 3 more facts
- Commons category
- Tremorine
- chemical formula
- C₁₂H₂₀N₂
- canonical SMILES
- C1CCN(C1)CC#CCN2CCCC2
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- History
- References
- See also
Tremorine is a drug which is used in scientific research to produce tremor in animals. This is used for the development of drugs for the treatment of Parkinson's disease, as tremor is a major symptom which is treated by anti-Parkinson's drugs. Beta blockers are also effective in counteracting the effects of tremorine.
== History == Tremorine was first reported by Everett et al. in 1956–57.
Excerpted from Wikipedia’s “tremorine” article, available under the CC BY-SA 4.0 licence.