TSHB

Name

thyroid stimulating hormone subunit beta

Type

protein-coding

Position

115,029,826–115,034,302 (+)

Aliases

TSH-B, TSH-BETA

Ensembl

ENSG00000134200

RefSeq RNA

NM_000549.5, NM_001277991.1

RefSeq protein

NP_000540.2, NP_001264920.1

The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013].