English

English Deutsch Español Français Italiano Nederlands Português Svenska العربية 中文

GeneQ18032201· pop 9· linked from 18 articles

TSHB

Sign in to save

Also known as TSH-B, TSH-BETA, thyroid stimulating hormone beta, Thyroid stimulating hormone, beta, thyroid stimulating hormone subunit beta

Thyroid stimulating hormone, beta also known as TSHB is a protein which in humans is encoded by the TSHB gene.

Gene data

TSHB

Name: thyroid stimulating hormone subunit beta
Type: protein-coding
Position: 115,029,826–115,034,302 (+)
Aliases: TSH-B, TSH-BETA
Ensembl: ENSG00000134200
RefSeq RNA: NM_000549.5, NM_001277991.1
RefSeq protein: NP_000540.2, NP_001264920.1

The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013].

Gene Ontology

Biological process

signal transduction G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway cell-cell signaling anatomical structure morphogenesis hormone-mediated signaling pathway

Molecular function

signaling receptor binding hormone activity hormone activity hormone activity

Cellular component

extracellular region extracellular region extracellular region

Pathways

cAMP signaling pathway - Homo sapiens (human)Neuroactive ligand-receptor interaction - Homo sapiens (human)Thyroid hormone synthesis - Homo sapiens (human)Regulation of lipolysis in adipocytes - Homo sapiens (human)Autoimmune thyroid disease - Homo sapiens (human)Metabolism Signal Transduction Metabolism of amine-derived hormones Glycoprotein hormones Peptide hormone biosynthesis

via MyGene.info

Gene · Ensembl

thyroid stimulating hormone subunit beta

Symbol: TSHB
Biotype: Protein coding
Organism: Homo sapiens
Location: 1:115,029,826-115,034,302
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 463
exact match: identifiers.org/ncbigene/7252
genomic end: 115034302
genomic start: 115029826
cytogenetic location: 1p13.2

Sources (3)

via Wikidata · CC0

~1 min read

Article

4 sections

Contents

Function
See also
References
Further reading

Thyroid stimulating hormone, beta also known as TSHB is a protein which in humans is encoded by the TSHB gene.

== Function ==

Available in 9 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 1