UFD1
Sign in to saveAlso known as UFD1L, ubiquitin fusion degradation 1 like (yeast), ubiquitin recognition factor in ER associated degradation 1
Ubiquitin fusion degradation protein 1 homolog is a protein that in humans is encoded by the UFD1L gene.
Gene data
UFD1- Name
- ubiquitin recognition factor in ER associated degradation 1
- Type
- protein-coding
- Aliases
- UFD1L
The protein encoded by this gene forms a complex with two other proteins, nuclear protein localization-4 and valosin-containing protein, and this complex is necessary for the degradation of ubiquitinated proteins. In addition, this complex controls the disassembly of the mitotic spindle and the formation of a closed nuclear envelope after mitosis. Mutations in this gene have been associated with Catch 22 syndrome as well as cardiac and craniofacial defects. Alternative splicing results in multiple transcript variants encoding different isoforms. A related pseudogene has been identified on chromosome 18. [provided by RefSeq, Jun 2009].
via MyGene.info
Gene · Ensembl
ubiquitin recognition factor in ER associated degradation 1
- Symbol
- UFD1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 22:19,449,899-19,479,695
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 39090
- exact match
- identifiers.org/ncbigene/7353
- genomic end
- 19479202
- genomic start
- 19449911
- cytogenetic location
- 22q11.21
Sources (4)
via Wikidata · CC0
~1 min read
Article
4 sectionsContents
- Function
- Interactions
- References
- Further reading
Ubiquitin fusion degradation protein 1 homolog is a protein that in humans is encoded by the UFD1L gene.
== Function ==