URI1

Also known as C19orf2, NNX3, PPP1R19, RMP, URI, URI1 prefoldin-like chaperone, URI1, prefoldin like chaperone, URI1 prefoldin like chaperone

Unconventional prefoldin RPB5 interactor, also called URI1, is a protein that in humans is encoded by the URI1 gene.

Gene data

URI1

Name: URI1 prefoldin like chaperone
Type: protein-coding
Position: 29,923,644–30,016,612 (+)
Aliases: C19orf2, NNX3, PPP1R19, RMP, URI
Ensembl: ENSG00000105176
RefSeq RNA: NM_001252641.2, NM_003796.3, NM_134447.1, NR_045557.1, XM_005259362.3
RefSeq protein: NP_001239570.1, NP_003787.2, XP_005259419.1, XP_005259420.1, XP_011525737.1

This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22. [provided by RefSeq, Nov 2011].