uroplakin 1B
Sign in to saveAlso known as UPK1B, uroplakin Ib, UP1b, UPIb, tetraspan, tspan-20, uroplakin-1b, tetraspanin-20
Uroplakin-1b (UP1b), is a protein which in humans is encoded by the UPK1B gene.
Protein · UniProt
Uroplakin-1b
- Gene
- UPK1B
- Organism
- Homo sapiens (Human)
- Length
- 260 aa
- Molecular mass
- 29,643 Da
- Evidence
- 1: Evidence at protein level
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity)
Swiss-Prot (reviewed) · via UniProt
Research
94 papers- Uroplakin 1b is critical in urinary tract development and urothelial differentiation and homeostasis.Kidney international · 2016
- Large-scale human tissue analysis identifies Uroplakin 1b as a putative diagnostic marker in surgical pathology.Human pathology · 2022
- Cloning of the human uroplakin 1B cDNA and analysis of its expression in urothelial-tumor cell lines and bladder-carcinoma tissue.International journal of cancer · 1999
- Human uroplakin Ib in ocular surface epithelium.Investigative ophthalmology & visual science · 2000
- Uroplakin III-delta4 messenger RNA as a promising marker to identify nonulcerative interstitial cystitis.The Journal of urology · 2007
via PubMed
~1 min read
Encyclopedic overview
3 sectionsContents
- Function
- References
- Further reading
Uroplakin-1b (UP1b), is a protein which in humans is encoded by the UPK1B gene.
== Function == The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. These proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The AUM is believed to be involved in strengthening the cells that line the bladder, and in enhancing the inner bladder membrane's ability to stretch, thus preventing these cells from rupturing during bladder distension. The use of alternate polyadenylation sites has been found for this gene.
Excerpted from Wikipedia’s “uroplakin 1B” article, available under the CC BY-SA 4.0 licence.