UVRAG
Sign in to saveAlso known as DHTX, VPS38, p63, UV radiation resistance associated
UV radiation resistance-associated gene protein is a protein that in humans is encoded by the UVRAG gene.
Gene data
UVRAG- Name
- UV radiation resistance associated
- Type
- protein-coding
- Aliases
- DHTX, VPS38, p63
This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
UV radiation resistance associated
- Symbol
- UVRAG
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:75,815,174-76,144,259
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 31150
- exact match
- identifiers.org/ncbigene/7405
- genomic end
- 76144232
- genomic start
- 75815210
- cytogenetic location
- 11q13.5
Sources (3)
via Wikidata · CC0
~1 min read
Article
2 sectionsContents
- References
- Further reading
UV radiation resistance-associated gene protein is a protein that in humans is encoded by the UVRAG gene.
This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells.