VPS4B

Name

vacuolar protein sorting 4 homolog B

Type

protein-coding

Position

63,389,119–63,422,521 (−)

Aliases

DTDP1B, MIG1, SKD1, SKD1B, VPS4-2

Ensembl

ENSG00000119541

RefSeq RNA

NM_004869.4, XM_047437949.1, XM_054319378.1

RefSeq protein

NP_004860.2, XP_047293905.1, XP_054175353.1

The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16. [provided by RefSeq, Jul 2008].

via MyGene.info

Gene · Ensembl

vacuolar protein sorting 4 homolog B

Symbol

VPS4B

Biotype

Protein coding

Organism

Homo sapiens

Location

18:63,389,119-63,422,521

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

Image

Protein VPS4B PDB 1wr0.png

via Wikidata · CC0