WDFY3

Also known as ALFY, ZFYVE25, WD repeat and FYVE domain containing 3, BCHS, MCPH18

WD repeat and FYVE domain-containing protein 3 is a protein that in humans is encoded by the WDFY3 gene.

Gene data

WDFY3

Name: WD repeat and FYVE domain containing 3
Type: protein-coding
Position: 84,668,765–84,966,690 (−)
Aliases: ALFY, BCHS, MCPH18, ZFYVE25
Ensembl: ENSG00000163625
RefSeq RNA: NM_014991.6, NM_178583.2, NM_178585.2, XM_005262858.6, XM_011531757.4
RefSeq protein: NP_055806.2, XP_005262915.1, XP_011530059.1, XP_011530061.1, XP_011530062.1

This gene encodes a phosphatidylinositol 3-phosphate-binding protein that functions as a master conductor for aggregate clearance by autophagy. This protein shuttles from the nuclear membrane to colocalize with aggregated proteins, where it complexes with other autophagic components to achieve macroautophagy-mediated clearance of these aggregated proteins. However, it is not necessary for starvation-induced macroautophagy. [provided by RefSeq, May 2010].

Gene Ontology

Biological process

macroautophagy

~1 min read

Article

4 sections

Contents

Biochemistry
Clinical
References
Further reading

WD repeat and FYVE domain-containing protein 3 is a protein that in humans is encoded by the WDFY3 gene.

This gene encodes a protein which contains WD repeats and an FYVE domain. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.