XDH

Name

xanthine dehydrogenase

Type

protein-coding

Position

31,334,320–31,414,747 (−)

Aliases

XAN1, XDH/XO, XO, XOR

Ensembl

ENSG00000158125

RefSeq RNA

NM_000379.4, NM_001445987.1, XM_011533095.3, XM_011533096.3, XM_054343771.1

RefSeq protein

NP_000370.2, NP_001432916.1, XP_011531397.1, XP_011531398.1, XP_054199746.1

Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. [provided by RefSeq, Jan 2014].

via MyGene.info

Gene · Ensembl

xanthine dehydrogenase

Symbol

XDH

Biotype

Protein coding

Organism

Homo sapiens

Location

2:31,334,320-31,414,756

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Image

Protein XDH PDB 1fiq.png

via Wikidata · CC0