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A-836,339
Sign in to saveA-836,339 is a drug developed by Abbott Laboratories that acts as a potent cannabinoid receptor full agonist. It is selective for CB2, with Ki values of 0.64 nM at CB2 vs 270 nM at the psychoactive CB1 receptor, but while it exhibits selective analgesic, anti-inflammatory and anti-hyperalgesic effects at low doses, its high efficacy at both targets results in typical cannabis-like effects appearing at higher doses, despite its low binding affinity for CB1. In 2012 A-836,339 was detected via X-ray crystallography in a "dubious product" sold in Japan, though the product was described a
In the Vinony graph
Within Vinony's link graph, A-836,339 is referenced by 501 other articles, and connects out to synthetic cannabinoid, synhexyl and JWH-210.
It sits within the topics Cannabinoids, Carboxamides and Chemical pages without DrugBank identifier.
Its subject is documented across 5 Wikipedia language editions.
Chemical data
- Formula
- C16H26N2O2S
- Molecular weight
- 310.5 g/mol
- IUPAC name
- N-[3-(2-methoxyethyl)-4,5-dimethyl-1,3-thiazol-2-ylidene]-2,2,3,3-tetramethylcyclopropane-1-carboxamide
- SMILES
- CC1=C(SC(=NC(=O)C2C(C2(C)C)(C)C)N1CCOC)C
- InChIKey
- JKGIMVBQKSRTGX-UHFFFAOYSA-N
- XLogP
- 3.2
- Polar surface area
- 67.2 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 310.171499
Show 2 more facts
- chemical formula
- C₁₆H₂₆N₂O₂S
- canonical SMILES
- CC1=C(SC(=NC(=O)C2C(C2(C)C)(C)C)N1CCOC)C
Sources (1)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
A-836,339 is a drug developed by Abbott Laboratories that acts as a potent cannabinoid receptor full agonist. It is selective for CB2, with Ki values of 0.64 nM at CB2 vs 270 nM at the psychoactive CB1 receptor, but while it exhibits selective analgesic, anti-inflammatory and anti-hyperalgesic effects at low doses, its high efficacy at both targets results in typical cannabis-like effects appearing at higher doses, despite its low binding affinity for CB1. In 2012 A-836,339 was detected via X-ray crystallography in a "dubious product" sold in Japan, though the product was described as a white powder, not herbal incense, it was suggested to be for human consumption.
== References ==
Excerpted from Wikipedia’s “A-836,339” article, available under the CC BY-SA 4.0 licence.