acetohexamide

Also known as Dymelor®, N-(p-Acetylphenylsulfonyl)-N'-cyclohexylurea, 4-Acetyl-N-((cyclohexylamino)carbonyl)benzenesulfonamide, 1-((p-Acetylphenyl)sulfonyl)-3-cyclohexylurea, Dymelor

Acetohexamide (trade name Dymelor) is a first-generation sulfonylurea medication used to treat diabetes mellitus type 2, particularly in people whose diabetes cannot be controlled by diet alone.

Chemical data

Formula: C15H20N2O4S
Molecular weight: 324.4 g/mol
IUPAC name: 1-(4-acetylphenyl)sulfonyl-3-cyclohexylurea
SMILES: CC(=O)C1=CC=C(C=C1)S(=O)(=O)NC(=O)NC2CCCCC2
InChIKey: VGZSUPCWNCWDAN-UHFFFAOYSA-N
XLogP: 2.4
Polar surface area: 101 Å²
H-bond donors: 2
H-bond acceptors: 4
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1964
Admin. routes: oral
Indications: diabetes mellitus, cataract

via ChEMBL · EBI

Research

311 papers

Acetohexamide.2006
Sulfonylureas, First Generation.2012
CURRENT THERAPEUTICS. CCII. ACETOHEXAMIDE.The Practitioner · 1964
Urate excretion.Annual review of medicine · 1977
In Vitro Investigations of Acetohexamide Binding to Glycated Serum Albumin in the Presence of Fatty Acid.Molecules (Basel, Switzerland) · 2020

via PubMed

Wikidata facts

Subclass of: chemical compound
Mass: 324.114378
Has use: medication

Show 8 more facts

chemical formula: C₁₅H₂₀N₂O₄S
isomeric SMILES: CC(=O)C1=CC=C(C=C1)S(=O)(=O)N/C(=N\C2CCCCC2)/O
canonical SMILES: CC(=O)C1=CC=C(C=C1)S(=O)(=O)NC(=O)NC2CCCCC2
World Health Organisation international non-proprietary name: acetohexamide
defined daily dose: 0.5
subject has role: anti-diabetic medication
stylized name: acetoHEXAMIDE
Commons category: Acetohexamide

Sources (4)

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Encyclopedic overview

3 sections

Contents

Mechanism of action
Risks
References

Acetohexamide (trade name Dymelor) is a first-generation sulfonylurea medication used to treat diabetes mellitus type 2, particularly in people whose diabetes cannot be controlled by diet alone.

==Mechanism of action==

Excerpted from Wikipedia’s “acetohexamide” article, available under the CC BY-SA 4.0 licence.

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