achlorhydria
Sign in to saveAlso known as hypochlorhydria
Achlorhydria and hypochlorhydria are states where the production of hydrochloric acid in gastric secretions of the stomach is absent or low, respectively. Achlorhydria is commonly a complication of some other disease, such as chronic Helicobacter pylori infection or autoimmune pernicious anemia, as well as a possible side effect of long-term use of proton pump inhibitors.
Key facts
- Medical condition (new).symptoms
- Most of the time none, but may cause and not limited to, epigastric pain, other abdominal pain, unintentional weight loss, heartburn, nausea, vomiting, bloating, diarrhea, early satiety
- Medical condition (new).complications
- Small intestinal bacterial overgrowth, nutrient deficiencies, gastric adenocarcinoma (rare), gastric carcinoid tumor (rare)
- Medical condition (new).causes
- Pernicious anemia, helicobacter pylori infection, hypothyroidism, gastric bypass surgery, VIPoma, chronic PPI use, gastric cancer, (rarely) radiotherapy
- Medical condition (new).treatment
- Addressing underlying cause and managing SIBO and nutrient deficiencies
- Medical condition (new).name
- Achlorhydria
- Medical condition (new).synonyms
- Hypochlorhydria
- Medical condition (new).image
- Hydrogen-chloride-3D-vdW-labelled.svg
- Medical condition (new).caption
- Hydrogen chloride (major component of gastric acid)
- Medical condition (new).field
- Internal medicine
via Wikipedia infobox
Research
1,882 papers- Is achlorhydria a cause of iron deficiency anemia?The American journal of clinical nutrition · 2015
- Achlorhydria: hypergastrinaemia: carcinoids--a flawed hypothesis?Gut · 1987
- Achlorhydria is associated with gastric microbial overgrowth and development of cancer: lessons learned from the gastrin knockout mouse.Scandinavian journal of clinical and laboratory investigation · 2006
- ACHLORHYDRIA and anaemia.Lancet (London, England) · 1960
- The achlorhydria-carcinoid sequence: role of gastrin.Digestion · 1988
via PubMed
Wikidata facts
- Image
- Cell parietal.png
via Wikidata · CC0
~8 min read
Article
9 sectionsContents
- Signs and symptoms
- Causes
- Risk factors
- Diagnosis
- Treatment
- Prognosis
- See also
- References
- External links
Achlorhydria and hypochlorhydria are states where the production of hydrochloric acid in gastric secretions of the stomach is absent or low, respectively. Achlorhydria is commonly a complication of some other disease, such as chronic Helicobacter pylori infection or autoimmune pernicious anemia, as well as a possible side effect of long-term use of proton pump inhibitors.
Complications of achlorhydria most frequently include small intestinal bacterial overgrowth and the nutritional deficiencies that can result from it. Rarely, achlorhydria may contribute to formation of gastric cancers or gastric carcinoid tumors.