gastrin
Sign in to saveAlso known as uniprot:P01350, preprogastrin, GAST
Gastrin is a peptide hormone that stimulates secretion of gastric acid (HCl) by the parietal cells of the stomach and aids in gastric motility. It is released by G cells in the pyloric antrum of the stomach, duodenum, and the pancreas.
Key facts
- Protein family.Symbol
- Gastrin
- Protein family.Name
- Gastrin
- Protein family.Pfam
- PF00918
- Protein family.InterPro
- IPR001651
- Protein family.PROSITE
- PDOC00232
via Wikipedia infobox
Protein · UniProt
Gastrin
- Gene
- GAST
- Organism
- Homo sapiens (Human)
- Length
- 101 aa
- Molecular mass
- 11,394 Da
- Evidence
- 1: Evidence at protein level
Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine
Swiss-Prot (reviewed) · via UniProt
Clinical Trials
50 registered- PHASE1/PHASE2RECRUITINGThe Value of GRPR PET Imaging for Diagnosis and Staging in Prostate CancerFirst Affiliated Hospital of Fujian Medical University · NCT07363382
- PHASE1/PHASE2TERMINATED64Cu-SAR-BBN and 67CU SAR-BBN for Identification and Treatment of Gastrin Releasing Peptide Receptor (GRPR)-Expressing Metastatic Castrate Resistant Prostate Cancer in Patients Who Are Ineligible for Therapy With 177Lu-PSMA-617 (COMBAT)Clarity Pharmaceuticals Ltd · NCT05633160
- PHASE1/PHASE2RECRUITINGA Phase I/II, Dose Finding and Optimization Study of [177Lu]Lu-NeoB in Combination With Capecitabine in Patients With GRPR+, ER+, HER2- Metastatic Breast Cancer After Progression on Previous Endocrine Therapy in Combination With a CDK4/6 Inhibitor.Novartis Pharmaceuticals · NCT06247995
- PHASE1UNKNOWN68Ga-NOTA-PEG2-RM26 PET/CT, First in Man StudyKarolinska University Hospital · NCT06147362
- PHASE1COMPLETEDEffect of 5, 10 or 25 mg of YF476 Daily for 14 Days on Stomach Acidity in Healthy VolunteersTrio Medicines Ltd. · NCT01597674
- PHASE2TERMINATED[68Ga]-NeoBOMB1 Imaging in Patients With Malignancies Known to Overexpress Gastrin Releasing Peptide Receptor (GRPR)Advanced Accelerator Applications · NCT03724253
Wikidata facts
Show 1 more fact
- exact match
- purl.uniprot.org/uniprot/P01350
Sources (3)
via Wikidata · CC0
~6 min read
Article
18 sectionsContents
- Physiology
- Genetics
- Synthesis
- Release
- Function
- Factors influencing secretion
- Physiologic
- Gastric lumen
- Paracrine
- Nervous
- Circulation
- Pathophysiologic
- Paraneoplastic
- Role in disease
- History
- References
- Further reading
- External links
Gastrin is a peptide hormone that stimulates secretion of gastric acid (HCl) by the parietal cells of the stomach and aids in gastric motility. It is released by G cells in the pyloric antrum of the stomach, duodenum, and the pancreas.
Gastrin binds to cholecystokinin B receptors to stimulate the release of histamines in enterochromaffin-like cells, and it induces the insertion of K+/H+ ATPase pumps into the apical membrane of parietal cells (which in turn increases H+ release into the stomach cavity). Its release is stimulated by peptides in the lumen of the stomach.