pentagastrin
Sign in to saveAlso known as Peptavlon, ICI-50123, AY-6608
Pentagastrin (trade name Peptavlon) is a synthetic polypeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid as the pentagastrin-stimulated calcitonin test.
Key facts
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 464198043
- Drug.IUPAC_name
- N-(tert-butoxycarbonyl)-β-alanyl-L-tryptophyl-L-methionyl-L-α-aspartyl-L-phenylalaninamide
- Drug.image
- Pentagastrin.svg
- Drug.image_class
- skin-invert-image
- Drug.elimination_half life
- 10 minutes or less
- Drug.CAS_number
- 5534-95-2
- Drug.ATC_prefix
- V04
- Drug.ATC_suffix
- CG04
- Drug.PubChem
- 9853654
- Drug.IUPHAR_ligand
- 870
- Drug.DrugBank
- DB00183
- Drug.ChemSpiderID
- 8029364
- Drug.UNII
- EF0NX91490
- Drug.KEGG
- D01631
- Drug.ChEMBL
- 1328
- Drug.C
- 37
- Drug.H
- 49
via Wikipedia infobox
Research
5,118 papers- Pentagastrin.The Medical letter on drugs and therapeutics · 1975
- Pentagastrin-induced thrombocytopenia.Lancet (London, England) · 1985
- Pentagastrin test for anxiety--psychophysiology and personality.Psychopharmacology · 2003
- Pentagastrin has panic-inducing properties in obsessive compulsive disorder.Psychopharmacology · 1996
- [Trophic effect of gastroenteric hormones pentagastrin and glucagon on the mucosa of the small intestine].Polski tygodnik lekarski (Warsaw, Poland : 1960) · 1989
via PubMed
Wikidata facts
- Has part
- carbon
- Mass
- 767.331247
- Has use
- medication
Show 3 more facts
- chemical formula
- C₃₇H₄₉N₇O₉S
- isomeric SMILES
- CC(C)(C)OC(=O)NCCC(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N
- canonical SMILES
- CC(C)(C)OC(=O)NCCC(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CCSC)C(=O)NC(CC(=O)O)C(=O)NC(CC3=CC=CC=C3)C(=O)N
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
4 sectionsContents
- Pentagastrin stimulation test
- Calcitonin test
- See also
- References
Pentagastrin (trade name Peptavlon) is a synthetic polypeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid as the pentagastrin-stimulated calcitonin test.
Pentagastrin binds to the cholecystokinin-B receptor, which is expressed widely in the brain. Activation of these receptors activates the phospholipase C second messenger system. When given intravenously it may cause panic attacks.
Excerpted from Wikipedia’s “pentagastrin” article, available under the CC BY-SA 4.0 licence.
Available in 13 languages
via Wikidata sitelinks · CC0