ceruletide

Also known as caerulein, cerulein, ceruletide diethylamine, Tymtran®, Caerulein, Ceruletidum, Cerulein

Ceruletide (INN), also known as cerulein or caerulein, is a ten amino acid oligopeptide that stimulates smooth muscle and increases digestive secretions. Ceruletide is similar in action and composition to cholecystokinin. It stimulates gastric, biliary, and pancreatic secretion; and certain smooth muscle. It is used in paralytic ileus and as diagnostic aid in pancreatic malfunction. It is used to induce pancreatitis in experimental animal models.

Research

3,220 papers

Ceruletide for schizophrenia: a review.Psychopharmacology bulletin · 1986
Caerulein (ceruletide). A review.Acta gastro-enterologica Belgica · 1976
Pharmacology, clinical uses, and adverse effects of ceruletide, a cholecystokinetic agent.Pharmacotherapy · 1982
Ceruletide acts in the abdomen, not in the brain, to produce satiety.Peptides · 1984
Ceruletide inhibits phencyclidine-induced dopamine and serotonin release in rat prefrontal cortex.Pharmacology, biochemistry, and behavior · 1998

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Wikidata facts

Mass: 1351.448538

Show 4 more facts

chemical formula: C₅₈H₇₃N₁₃O₂₁S₂
canonical SMILES: CC(C(C(=O)NCC(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CCSC)C(=O)NC(CC(=O)O)C(=O)NC(CC3=CC=CC=C3)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)OS(=O)(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)N)NC(=O)C5CCC(=O)N5)O
isomeric SMILES: C[C@H]([C@@H](C(=O)NCC(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N)NC(=O)[C@H](CC4=CC=C(C=C4)OS(=O)(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H]5CCC(=O)N5)O
World Health Organisation international non-proprietary name: ceruletide

Sources (2)

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Article

3 sections

Contents

Induction of pancreatitis
See also
References

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