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bentiromide
Sign in to saveAlso known as Chymex, E-2663, BTPABA, PFT, Btpaba Pft, Bentiromido, Bentiromidum
Bentiromide is a peptide used as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy. Bentiromide is not available in the United States or Canada; it was withdrawn in the US in October 1996.
Chemical data
- Formula
- C23H20N2O5
- Molecular weight
- 404.4 g/mol
- IUPAC name
- 4-[[(2S)-2-benzamido-3-(4-hydroxyphenyl)propanoyl]amino]benzoic acid
- SMILES
- C1=CC=C(C=C1)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)NC3=CC=C(C=C3)C(=O)O
- InChIKey
- SPPTWHFVYKCNNK-FQEVSTJZSA-N
- XLogP
- 3.3
- Polar surface area
- 116 Ų
- H-bond donors
- 4
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1983
- Admin. routes
- oral
via ChEMBL · EBI
Research
171 papers- The bentiromide test for pancreatic exocrine insufficiency.Pharmacotherapy · 1984
- [PFD test (bentiromide test, BT-PABA test)].Nihon rinsho. Japanese journal of clinical medicine · 1997
- Bentiromide:xylose test in healthy cats.American journal of veterinary research · 1982
- The bentiromide test using plasma p-aminobenzoic acid for diagnosing pancreatic insufficiency in young children. The effect of two different doses and a liquid meal.Gastroenterology · 1991
- Bentiromide test is not affected in patients with small bowel disease or liver disease.Pancreas · 1987
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 404.137222
Show 4 more facts
- chemical formula
- C₂₃H₂₀N₂O₅
- canonical SMILES
- C1=CC=C(C=C1)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC3=CC=C(C=C3)C(=O)O
- isomeric SMILES
- C1=CC=C(C=C1)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)NC3=CC=C(C=C3)C(=O)O
- World Health Organisation international non-proprietary name
- bentiromide
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
6 sectionsContents
- Side effects
- Mechanism of action
- Chemistry
- Synthesis
- See also
- References
Bentiromide is a peptide used as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy. Bentiromide is not available in the United States or Canada; it was withdrawn in the US in October 1996.
== Side effects == Headache and gastrointestinal disturbances have been reported in patients taking bentiromide.
Excerpted from Wikipedia’s “bentiromide” article, available under the CC BY-SA 4.0 licence.
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