Structure via PubChem · Public domain (PubChem)
adatanserin
Sign in to saveAdatanserin (WY-50,324, SEB-324) is a mixed 5-HT1A receptor partial agonist and 5-HT2A and 5-HT2C receptor antagonist. It was under development by Wyeth as an antidepressant but was ultimately not pursued.
Chemical data
- Formula
- C21H31N5O
- Molecular weight
- 369.5 g/mol
- IUPAC name
- N-[2-(4-pyrimidin-2-ylpiperazin-1-yl)ethyl]adamantane-1-carboxamide
- SMILES
- C1CN(CCN1CCNC(=O)C23CC4CC(C2)CC(C4)C3)C5=NC=CC=N5
- InChIKey
- HPFLVTSWRFCPCV-UHFFFAOYSA-N
- XLogP
- 2.4
- Polar surface area
- 61.4 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 369.253
Show 3 more facts
- chemical formula
- C₂₁H₃₁N₅O
- canonical SMILES
- C1CN(CCN1CCNC(=O)C23CC4CC(C2)CC(C4)C3)C5=NC=CC=N5
- Commons category
- Adatanserin
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Synthesis
- See also
- References
Adatanserin (WY-50,324, SEB-324) is a mixed 5-HT1A receptor partial agonist and 5-HT2A and 5-HT2C receptor antagonist. It was under development by Wyeth as an antidepressant but was ultimately not pursued.
Adantaserin has been shown to be neuroprotective against ischemia-induced glutamatergic excitotoxicity, an effect which appears to be mediated by blockade of the 5-HT2A receptor.
Excerpted from Wikipedia’s “adatanserin” article, available under the CC BY-SA 4.0 licence.