adatanserin
Sign in to saveAdatanserin (WY-50,324, SEB-324) is a mixed 5-HT1A receptor partial agonist and 5-HT2A and 5-HT2C receptor antagonist. It was under development by Wyeth as an antidepressant but was ultimately not pursued.
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 369.253
Show 3 more facts
- chemical formula
- C₂₁H₃₁N₅O
- canonical SMILES
- C1CN(CCN1CCNC(=O)C23CC4CC(C2)CC(C4)C3)C5=NC=CC=N5
- Commons category
- Adatanserin
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Encyclopedic overview
3 sectionsContents
- Synthesis
- See also
- References
Adatanserin (WY-50,324, SEB-324) is a mixed 5-HT1A receptor partial agonist and 5-HT2A and 5-HT2C receptor antagonist. It was under development by Wyeth as an antidepressant but was ultimately not pursued.
Adantaserin has been shown to be neuroprotective against ischemia-induced glutamatergic excitotoxicity, an effect which appears to be mediated by blockade of the 5-HT2A receptor.
Excerpted from Wikipedia’s “adatanserin” article, available under the CC BY-SA 4.0 licence.