aglepristone

Also known as (8S,11R,13S,14S,17R)-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-[(Z)-prop-1-enyl]-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one

Aglepristone () (brand name Alizin; former developmental code names RU-46534, RU-534) is a synthetic, steroidal antiprogestogen related to mifepristone. Aglepristone, similarly to mifepristone, also possesses some antiglucocorticoid activity. Aglepristone is used as an abortifacent, to induce parturition, and as a treatment for mammary hyperplasia and pyometra. It is only used in cats and dogs. == See also == Lilopristone Onapristone Telapristone Toripristone

Chemical data

Formula: C29H37NO2
Molecular weight: 431.6 g/mol
IUPAC name: (8S,11R,13S,14S,17R)-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-[(Z)-prop-1-enyl]-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
SMILES: C/C=C\[C@@]1(CC[C@@H]2[C@@]1(C[C@@H](C3=C4CCC(=O)C=C4CC[C@@H]23)C5=CC=C(C=C5)N(C)C)C)O
InChIKey: RTCKAOKDXNYXEH-FWSJOHTJSA-N
XLogP: 4
Polar surface area: 40.5 Å²
H-bond donors: 1
H-bond acceptors: 3
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 2
Molecule type: Small molecule

via ChEMBL · EBI

Wikidata facts

Subclass of: chemical compound
Mass: 431.28242942400004

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canonical SMILES: CC=CC1(CCC2C1(CC(C3=C4CCC(=O)C=C4CCC23)C5=CC=C(C=C5)N(C)C)C)O
isomeric SMILES: C/C=C\[C@@]1(CC[C@@H]2[C@@]1(C[C@@H](C3=C4CCC(=O)C=C4CC[C@@H]23)C5=CC=C(C=C5)N(C)C)C)O
chemical formula: C₂₉H₃₇NO₂

Sources (2)

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Encyclopedic overview

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Contents

See also
References

== References ==

Excerpted from Wikipedia’s “aglepristone” article, available under the CC BY-SA 4.0 licence.

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