Alamethicin
Sign in to saveAlamethicin is a channel-forming peptide antibiotic, produced by the fungus Trichoderma viride. It belongs to peptaibol peptides which contain the non-proteinogenic amino acid residue Aib (2-aminoisobutyric acid). This residue strongly induces formation of alpha-helical structure. The peptide sequence is
Research
1,264 papers- The conformational properties of alamethicin in ethanol studied by NMR.European biophysics journal : EBJ · 2024
- Alamethicin channel inactivation caused by voltage-driven flux of alamethicin.Biochimica et biophysica acta. Biomembranes · 2024
- Alamethicin and related membrane channel forming polypeptides.Molecular and cellular biochemistry · 1983
- The history of alamethicin: a review of the most extensively studied peptaibol.Chemistry & biodiversity · 2007
- Alamethicin: a peptide model for voltage gating and protein-membrane interactions.Annual review of biophysics and biomolecular structure · 1994
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Encyclopedic overview
3 sectionsContents
- Biosynthesis
- References
- Further reading
Alamethicin is a channel-forming peptide antibiotic, produced by the fungus Trichoderma viride. It belongs to peptaibol peptides which contain the non-proteinogenic amino acid residue Aib (2-aminoisobutyric acid). This residue strongly induces formation of alpha-helical structure. The peptide sequence is Ac-Aib-Pro-Aib-Ala-Aib-Ala-Gln-Aib-Val-Aib-Gly-Leu-Aib-Pro-Val-Aib-Aib-Glu-Gln-Phl
where Ac = acetyl, Phl = phenylalaninol, and Aib = 2-Aminoisobutyric acid.
Excerpted from Wikipedia’s “Alamethicin” article, available under the CC BY-SA 4.0 licence.