gentamicin

Also known as gentamicin sulfate, gentamycin, gentamicins

Gentamicin is an aminoglycoside antibiotic used to treat several types of bacterial infections. This may include bone infections, endocarditis, pelvic inflammatory disease, meningitis, pneumonia, urinary tract infections, and sepsis among others. It can be given intravenously, by intramuscular injection, or topically. Topical formulations may be used in burns or for infections of the outside of the eye. It is often only used for two days until bacterial cultures determine what specific antibiotics the infection is sensitive to. The dose required should be monitored by blood testing.

Chemical data

Formula: C21H43N5O7
Molecular weight: 477.6 g/mol
IUPAC name: 2-[4,6-diamino-3-[3-amino-6-[1-(methylamino)ethyl]oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol
SMILES: CC(C1CCC(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)NC
InChIKey: CEAZRRDELHUEMR-UHFFFAOYSA-N
XLogP: -4.1
Polar surface area: 200 Å²
H-bond donors: 8
H-bond acceptors: 12
Formal charge: 0

via PubChem

Research

38,434 papers

Gentamicin vestibulotoxicity.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 1994
Gentamicin in 1978.Annals of internal medicine · 1978
Gentamicin-induced anaphylaxis.Irish journal of medical science · 2007
Use of Gentamicin as Empiric Coverage for Ventilator-Associated Pneumonia: The "Con" Perspective.Surgical infections · 2016
Microbial biosynthesis and applications of gentamicin: a critical appraisal.Critical reviews in biotechnology · 2008

via PubMed

Wikidata facts

Mass: 477.316249
Image: Gentamicin for injection.jpg

Show 5 more facts

Commons category: Gentamicin
chemical formula: C₂₁H₄₃N₅O₇
canonical SMILES: CC(C1CCC(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)NC
defined daily dose: 0.24
NCI Thesaurus ID: C519

Sources (7)

via Wikidata · CC0

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Article

20 sections

Contents

Medical uses
Special populations
Pregnancy and breastfeeding
Elderly
Children
Contraindications
Adverse effects
Kidney damage
Inner ear
Pharmacology
Mechanism of action
Chemistry
Structure
Components
Biosynthesis
Fermentation
History
Research
References
Further reading

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