lincosamides

Also known as lincosamide

thumb|Lincomycin thumb|Clindamycin (note chlorine atom compared to lincomycin) Lincosamides are a class of antibiotics, which include lincomycin, clindamycin, and pirlimycin.

In the Vinony graph

Vinony's link graph records 125 inbound references to lincosamides, and connects out to antibiotic, neomycin and United States.

It is catalogued under the topic Lincosamides.

Vinony links it to 21 Wikipedia language editions.

Research

10,644 papers

Lincosamides: Chemical structure, biosynthesis, mechanism of action, resistance, and applications.Biochemical pharmacology · 2017
[Lincosamides].Pathologie-biologie · 1986
Lincosamides, Streptogramins, Phenicols, and Pleuromutilins: Mode of Action and Mechanisms of Resistance.Cold Spring Harbor perspectives in medicine · 2016
Lincosamides: chemical structure, biosynthesis, mechanism of action, resistance, and applications.Advances in applied microbiology · 2004
An antibiotic preorganized for ribosomal binding overcomes antimicrobial resistance.Science (New York, N.Y.) · 2024

via PubMed

~9 min read

Encyclopedic overview

15 sections

Contents

Structure
Synthesis
Mechanism of action
Resistance
Ribosomal methylation
Target mutation
Antibiotic efflux
Drug modification
Pharmacokinetics
Clinical use
Toxicity and interactions
Lincosamide brand name formulations
History
Further reading
References

thumb|Lincomycin thumb|Clindamycin (note chlorine atom compared to lincomycin) Lincosamides are a class of antibiotics, which include lincomycin, clindamycin, and pirlimycin.

== Structure == Lincosamides consist of a pyrrolidine ring linked to a pyranose moiety (methylthio-lincosamide) via an amide bond. Hydrolysis of lincosamides, specifically lincomycin, splits the molecule into its building blocks of the sugar and proline moieties. Both of these derivatives can conversely be recombined into the drug itself or a derivative.

Excerpted from Wikipedia’s “lincosamides” article, available under the CC BY-SA 4.0 licence.