telithromycin
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Telithromycin is the first ketolide antibiotic to enter clinical use and is sold under the brand name of Ketek. It is used to treat community acquired pneumonia of mild to moderate severity. After significant safety concerns, the US Food and Drug Administration sharply curtailed the approved uses of the drug in early 2007.
Research
1,019 papers- Telithromycin.Drugs · 2004
- Telithromycin.Expert review of anti-infective therapy · 2004
- [Telithromycin].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2004
- Telithromycin.Drugs · 2001
- Telithromycin.Annals of internal medicine · 2006
via PubMed
Wikidata facts
- Mass
- 811.473
Show 6 more facts
- chemical formula
- C₄₃H₆₅N₅O₁₀
- canonical SMILES
- CCC1C2(C(C(C(=O)C(CC(C(C(C(=O)C(C(=O)O1)C)C)OC3C(C(CC(O3)C)N(C)C)O)(C)OC)C)C)N(C(=O)O2)CCCCN4C=C(N=C4)C5=CN=CC=C5)C
- isomeric SMILES
- CC[C@@H]1[C@@]2([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H](C(=O)[C@H](C(=O)O1)C)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)OC)C)C)N(C(=O)O2)CCCCN4C=C(N=C4)C5=CN=CC=C5)C
- defined daily dose
- 0.8
- native label
- Telithromycinum
- Commons category
- Telithromycin
Sources (8)
via Wikidata · CC0
~9 min read
Article
10 sectionsContents
- Adverse effects
- Mechanism of action
- Pharmacokinetics
- Metabolism
- History
- Safety controversies and fraud
- FDA Warning
- Available forms
- References
- External links
Telithromycin is the first ketolide antibiotic to enter clinical use and is sold under the brand name of Ketek. It is used to treat community acquired pneumonia of mild to moderate severity. After significant safety concerns, the US Food and Drug Administration sharply curtailed the approved uses of the drug in early 2007.
Telithromycin is a semi-synthetic erythromycin derivative. It is created by substituting a ketogroup for the cladinose sugar and adding a carbamate ring in the lactone ring. An alkyl-aryl moiety is attached to this carbamate ring. Furthermore, the oxygen at the 6 position is methylated, as is the case with clarithromycin, to achieve better acid-stability.