alprenolol
Sign in to saveAlso known as 1-(o-allylphenoxy)-3-(isopropylamino)-2-propanol, 1-(2-allylphenoxy)-3-isopropylamino-2-propanol
Alprenolol, or alfeprol, alpheprol, and alprenololum (Gubernal, Regletin, Yobir, Apllobal, Aptine, Aptol Duriles), is a non-selective beta blocker as well as a 5-HT1A and 5-HT1B receptor antagonist, used in the treatment of angina pectoris. It is no longer marketed by AstraZeneca, but may still be available from other pharmaceutical companies or generically.
Research
2,673 papers- Alprenolol-induced thrombocytopenia.Acta medica Scandinavica · 1980
- Alprenolol in hypertension.Acta medica Scandinavica. Supplementum · 1974
- Alprenolol for migraine prophylaxis.Headache · 1975
- Alprenolol and bromoacetylalprenololmenthane are competitive slowly reversible antagonists at the beta 1-adrenoceptors of rat left atria.Journal of cardiovascular pharmacology · 1993
- Identification of Alprenolol Hydrochloride as an Anti-prion Compound Using Surface Plasmon Resonance Imaging.Molecular neurobiology · 2019
via PubMed
Wikidata facts
- Subclass of
- secondary alcohol
- Has part
- carbon
- Mass
- 249.172879
- Has use
- medication
Show 7 more facts
- chemical formula
- C₁₅H₂₃NO₂
- canonical SMILES
- CC(C)NCC(COC1=CC=CC=C1CC=C)O
- Commons category
- Alprenolol
- World Health Organisation international non-proprietary name
- alprenolol
- medical condition treated
- arterial hypertension
- physically interacts with
- adrenoceptor beta 2
- native label
- alprenolol
Sources (7)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Pharmacology
- Pharmacokinetics
- References
Alprenolol, or alfeprol, alpheprol, and alprenololum (Gubernal, Regletin, Yobir, Apllobal, Aptine, Aptol Duriles), is a non-selective beta blocker as well as a 5-HT1A and 5-HT1B receptor antagonist, used in the treatment of angina pectoris. It is no longer marketed by AstraZeneca, but may still be available from other pharmaceutical companies or generically.
==Pharmacology== ===Pharmacokinetics=== The brain-to-blood ratio of alprenolol in humans has been found to be 16:1. For comparison, the brain-to-blood ratio of the highly lipophilic propranolol was 15:1 to 26:1 and of the hydrophilic atenolol was 0.2:1.
Excerpted from Wikipedia’s “alprenolol” article, available under the CC BY-SA 4.0 licence.